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Description
PD-L1 Recombinant Rabbit mAb (SDT-R017)Product Specification Host Rabbit Antigen PD L1 Synonyms Programmed cell death 1 ligand 1, CD274, B7 H1 Immunogen N A Location Membrane Accession Q9NZQ7 Clone Number SDT R017 Antibody Type Rabbit mAb Application WB, IHC P, IF Reactivity Hu Purification Protein A Concentration 0. 5 mg ml Physical Appearance Liquid Storage Buffer PBS, 40% Glycerol, 0. 05% BSA, 0. 03% Proclin 300 Stability & Storage 12 months from date of receipt reconstitution, 20 C as
Product Specification
| Host | Rabbit |
| Antigen | PD-L1 |
| Synonyms | Programmed cell death 1 ligand 1, CD274, B7-H1 |
| Immunogen | N/A |
| Location | Membrane |
| Accession | Q9NZQ7 |
| Clone Number | SDT-R017 |
| Antibody Type | Rabbit mAb |
| Application | WB, IHC-P, IF |
| Reactivity | Hu |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| IHC-P | 1:500 | null |
| WB | 1:1000 | null |
| IF | 1:100 | null |
Background
Programmed death-ligand 1 (PD-L1) also known as cluster of differentiation 274 (CD274) or B7 homolog 1 (B7-H1) is a protein that in humans is encoded by the CD274 gene. Programmed death-ligand 1 (PD-L1) is a 40kDa type 1 transmembrane protein that has been speculated to play a major role in suppressing the adaptive arm of immune systems during particular events such as pregnancy, tissue allografts, autoimmune disease and other disease states such as hepatitis. The binding of PD-L1 to the inhibitory checkpoint molecule PD-1 transmits an inhibitory signal based on interaction with phosphatases (SHP-1 or SHP-2) via Immunoreceptor Tyrosine-Based Switch Motif (ITSM). This reduces the proliferation of antigen-specific T-cells in lymph nodes, while simultaneously reducing apoptosis in regulatory T cells (anti-inflammatory, suppressive T cells) - further mediated by a lower regulation of the gene Bcl-2. Upregulation of PD-L1 on immune cells (especially myeloid cells) can also lead to formation of an immunosuppressive environment in a highly localized manner that also allow the cancer cells to proliferate.
Shipping Notes
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Exchange/Return Notes
- We offer a 30-day return/exchange service after receiving.
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4.7 ★★★★★
Based on 18 reviews
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Product Reviews
★★★★★ 5
Espectacular
Es genial, tiene una potencia grandiosa.
Me encantó, la recomiendo 100%
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Reviewed in the United States on April 22, 2026
★★★★★ 4
Needs improvement
This trimmer really looks nice and it comes with some great attachments but what I found is that if you're going to switch from the line attachment to the little plastic attachment you have to sit somewhere where you can lay the item down because you have to unscrew one to put on the other. There is no way to easily switch from line trimming to attachment trimming without using the device that unhooks the screw. In my opinion that is really a detriment to the beauty of the overall working of this item the weight of it is good, it cuts good it automatically feeds the line out the color is nice and the price is great but then you have the issue of changing the line back and forth if this was improved I think I would definitely give it five stars I'm sorry but improvements need to be made.
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Reviewed in the United States on August 14, 2025
★★★★★ 5
This can do some cutting
So glad I purchased this for cutting thin annoying vines and really tall weeds. The resin blades have held up to cutting 1/2" stemmed vines, weeds, and tall johnson grass out on the farm. Have not had to change out the first set and it comes with 3 sets of blades, plus an allen wrench for changing out the rotating head to a wire weedeater. Very happy overall. Too, it is not heavy at all, and noticed the battery lasts longer compared to using the B&D 20v line weedeater .
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Reviewed in the United States on June 11, 2025
★★★★★ 5
Very nice for the price
They’ve thought of everything for this. Easily switch heads. Easily change from trimming to edging. The line auto advances keeping you going when many others make you stop and make adjustments.
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Reviewed in the United States on December 8, 2025
★★★★★ 2
Faulty Trigger
This was the 3rd of 4 B & D Weed Trimmer's I have purchased in the past 4 months. My first B & D Weed Trimmer was purchased 3 years ago. The Trigger finally gave out. Every B & D Weed Trimmer has had a faulty trigger. They give out just past the 30 day return window - trying to get B & D to cover it on their warranty website is ridiculous! No one at Amazon knows anything either. So you either buy another or go to Ryobi...because you cant find any decent replacement blades for it either.
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Reviewed in the United States on August 29, 2025