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Description
TROP2 His Tag Protein, MouseProduct Specification Species Mouse Synonyms TACSTD2, GA733 1, M1S1, TROP2 Accession Q8BGV3 Amino Acid Sequence Gln25 Gly270, with C terminal 8*His QSNCTCPTNKMTVCDTNGPGGVCQCRAMGSQVLVDCSTLTSKCLLLKARMSARKSGRSLVMPSEHAILDNDGLYDPECDDKGRFKARQCNQTSVCWCVNSVGVRRTDKGDQSLRCDEVVRTHHILIELRHRPTDRAFNHSDLDSELRRLFQERYKLHPSFLSAVHYEEPTIQIELRQNASQKGLRDVDIADAAYYFERDIKGESLFMGRRGLDVQVRGEPLHVERTLIYYLDEKPPQFSMKRLTAGGGGSHHHHHHHH Expression System HEK293 Molecular Weight 40
Product Specification
| Species | Mouse |
| Synonyms | TACSTD2, GA733-1, M1S1, TROP2 |
| Accession | Q8BGV3 |
| Amino Acid Sequence | Gln25-Gly270, with C-terminal 8*His QSNCTCPTNKMTVCDTNGPGGVCQCRAMGSQVLVDCSTLTSKCLLLKARMSARKSGRSLVMPSEHAILDNDGLYDPECDDKGRFKARQCNQTSVCWCVNSVGVRRTDKGDQSLRCDEVVRTHHILIELRHRPTDRAFNHSDLDSELRRLFQERYKLHPSFLSAVHYEEPTIQIELRQNASQKGLRDVDIADAAYYFERDIKGESLFMGRRGLDVQVRGEPLHVERTLIYYLDEKPPQFSMKRLTAGGGGSHHHHHHHH |
| Expression System | HEK293 |
| Molecular Weight | 40-50kDa |
| Purity | >95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference |
1、Ripani E. et al. (1998) Human Trop-2 is a tumor-associated calcium signal transducer. Int J Cancer. 76(5): 671-676. 2、Wang J. et al. (2008) Identification of Trop-2 as an oncogene and an attractive therapeutic target in colon cancers. Mol Cancer Ther. 7(2): 280-285. |
Background
Trophoblast cell-surface antigen 2 (TROP2), also known as tumor-associated calcium signal transducer 2 (TACSTD2), is a transmembrane glycoprotein with high homology to the epithelial cell. TROP2 was discovered first in trophoblast cells as a surface marker. Gene TACSTD2 located on chromosome 1p32 encodes TROP2. TROP2 consists of extracellular and transmembrane domains and a cytoplasmic tail. TROP2 undergoes intramembrane proteolysis and is cleaved into a large extracellular fragment and a short intracellular fragment. TROP2 increases intracellular calcium concentration, decreases fibronectin binding and cell adhesion, and increases cell motility. TROP2 is overexpressed in several carcinomas, such as colorectal, pancreatic, gastric, oral squamous cell carcinoma, ovarian, and breast cancers, compared with the corresponding normal tissue. Because TROP2 overexpression is associated with poor survival in patients with solid tumors, TROP2 has been considered a potential target for anticancer therapy. In studies of breast and lung cancers, TROP2 inhibition exerted anticancer effects.
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4.5 ★★★★★
Based on 30 reviews
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Product Reviews
★★★★★ 5
Comfortable Shoes Right Out of the Box
Size: 9, Color: Black
I bought these shoes for my husband. He has a very hard time finding quality, comfortable shoes. These shoes are just as comfortable as his New Balance. He uses them as a dress shoe and wears them at least once a week. There was no break in period necessary. They were comfortable right out of the box! The only thing we didn't like was the white sole color. Once I knew he was going to keep them, I used a black sharpie marker to color the soles black. Instant amazing, comfortable dress shoes. They were well worth the cost. If you or your SO needs a comfortable pair of shoes, we highly recommend them.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on September 2, 2025
★★★★★ 3
Decent Shoes with Misleading Description (Not Leather)
Size: 12 Wide, Color: Black, Size: 12 Wide, Color: Black
I only look for leather when I’m purchasing dress shoes. Under the description “details” on this item it lists the shoe as leather upper and inner lining. A photo shows “genuine Napa leather lining”. If you keep reading (which I have now that I’ve received the shoes) it shows “faux leather” in the small print and that is not “leather”. I run a small leather business and this irks me because it’s clearly false advertising. The details also show the product is made in Brazil but when they arrived today, the shoe tag shows “Made in China” and “Man Made upper and lower”. I don’t hate the shoes. They look nice. What I know is they won’t hold up over time like leather, which is why the description should be accurate and not misleading.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on March 28, 2026
★★★★★ 5
Men’s oxfords
Size: 10.5, Color: Black
Good quality and perfect fit
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on March 22, 2026
★★★★★ 1
Low quality
Size: 8.5 Wide, Color: Cognac, Size: 8.5 Wide, Color: Cognac
Starting to peel after a few uses
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Reviewed in the United States on June 3, 2026
★★★★★ 5
Elegant color, handsome, and sharp wear
Very nice quality, versatile color, very sharp and handsome to wear
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on June 8, 2025
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