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Description
SCARB2/SR-B2/LIMPII Fc Chimera Protein, MouseProduct Specification Species Mouse Synonyms SR B2, SCARB2, CD36L2, LIMP2, LIMPII Accession O35114 Amino Acid Sequence Arg27 Thr432, with C terminal hIgG1 Fc Expression System HEK293 Molecular Weight 82 95kDa (Reducing) Purity 95% by SDS PAGE Endotoxin <0. 1EU g Conjugation Unconjugated Tag Human Fc Tag Physical Appearance Lyophilized Powder Storage Buffer PBS, pH7. 4. Reconstitution Reconstitute at 0. 1 1 mg ml according to the size in ultrapure
Product Specification
| Species | Mouse |
| Synonyms | SR-B2, SCARB2, CD36L2, LIMP2, LIMPII |
| Accession | O35114 |
| Amino Acid Sequence | Arg27-Thr432, with C-terminal hIgG1 Fc |
| Expression System | HEK293 |
| Molecular Weight | 82-95kDa (Reducing) |
| Purity | ＞95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | Human Fc Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4. |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference | Neculai D. et al. (2013) Structure of LIMP-2 provides functional insights with implications for SR-BI and CD36. Nature. 504: 172-176. |
Background
LIMPII (Lysosomal Integral Membrane Protein II), also known as LPG85 (85 kDa lysosomal membrane sialoglycoprotein) and as CD36 antigen-like 2 (CD36L2), is a major lysosomal membrane protein. LIMP-II is a type-III protein that traverses the membrane twice, with an N-terminal transmembrane anchor as a result of an uncleaved signal peptide and a second membrane spanning region near the C-terminus, followed by a 20 amino acid cytoplasmic tail. LIMPII is currently known to be a member of a superfamily of scavenger receptor proteins (class B), which also includes scavenger receptor (SR)-B1 and SR-B3. These three proteins share their structure, which comprises two transmembrane domains, a relatively large extracellular domain, and both the amino and carboxyl termini located within the cytoplasm. LIMPII as the mannose-6-phosphate- independent trafficking receptor for beta-glucocerebrosidase.
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