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Description
p53 Recombinant Rabbit mAb (SDT-100-72)Product Specification Host Rabbit Antigen p53 Synonyms Antigen NY CO 13, Phosphoprotein p53, Tumor suppressor p53, TP53 Immunogen Synthetic Peptide Location Cytoplasm, Nucleus Accession P04637 Clone Number SDT 100 72 Antibody Type Rabbit mAb Application WB, IHC P, ICC, ICFCM Reactivity Hu Predicted Reactivity TrSw Purification Protein A Concentration 0. 25 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS, 40% Glycerol, 0.
Product Specification
| Host | Rabbit |
| Antigen | p53 |
| Synonyms | Antigen NY-CO-13, Phosphoprotein p53, Tumor suppressor p53, TP53 |
| Immunogen | Synthetic Peptide |
| Location | Cytoplasm, Nucleus |
| Accession | P04637 |
| Clone Number | SDT-100-72 |
| Antibody Type | Rabbit mAb |
| Application | WB, IHC-P, ICC, ICFCM |
| Reactivity | Hu |
| Predicted Reactivity | TrSw |
| Purification | Protein A |
| Concentration | 0.25 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05%BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| ICC | 1:500 | |
| ICFCM | 1:250 | |
| IHC-P | 1:1000 | |
| WB | 1:2500 |
Background
p53, also known as Tumor protein P53, cellular tumor antigen p53 (UniProt name), or transformation-related protein 53 (TRP53) is a regulatory protein that is often mutated in human cancers. The p53 proteins (originally thought to be, and often spoken of as, a single protein) are crucial in vertebrates, where they prevent cancer formation. As such, p53 has been described as "the guardian of the genome" because of its role in conserving stability by preventing genome mutation. Hence TP53 is classified as a tumor suppressor gene.
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