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Description
Phospho-Erk5 (Thr218/Tyr220) Recombinant Rabbit mAb (S-3538-42)Product Specification Host Rabbit Antigen Phospho Erk5 (Thr218 Tyr220) Synonyms Mitogen activated protein kinase 7; MAP kinase 7; MAPK 7; Big MAP kinase 1 (BMK 1); Extracellular signal regulated kinase 5 (ERK 5); BMK1; ERK5; PRKM7; MAPK7 Immunogen Synthetic Peptide Location Cytoplasm, Nucleus Accession Q13164 Clone Number S 3538 42 Antibody Type Recombinant mAb Isotype IgG Application WB Reactivity Hu, Ms Positive Sample HeLa (starved overnight, then
Product Specification
| Host | Rabbit |
| Antigen | Phospho-Erk5 (Thr218/Tyr220) |
| Synonyms | Mitogen-activated protein kinase 7; MAP kinase 7; MAPK 7; Big MAP kinase 1 (BMK-1); Extracellular signal-regulated kinase 5 (ERK-5); BMK1; ERK5; PRKM7; MAPK7 |
| Immunogen | Synthetic Peptide |
| Location | Cytoplasm, Nucleus |
| Accession | Q13164 |
| Clone Number | S-3538-42 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB |
| Reactivity | Hu, Ms |
| Positive Sample | HeLa (starved overnight, then treated with 50 ng/ml hEGF for 10 minutes), NIH/3T3 (starved overnight, then treated with 100 ng/ml PDGF for 5 minutes) |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu, Ms |
Background
Phospho-Erk5 (Thr218/Tyr220) is a phosphorylated form of the extracellular signal-regulated kinase 5 (Erk5), also known as big MAP kinase 1 (BMK1). It is activated through dual phosphorylation at threonine 218 and tyrosine 220 within its TEY activation motif by upstream MAP kinase kinases MEK5. This phosphorylation event is essential for Erk5 catalytic activity and its subsequent nuclear translocation, where it regulates gene expression involved in cell proliferation, survival, and differentiation. Phospho-Erk5 serves as a specific biomarker for Erk5 pathway activation in various cellular processes and disease states, including cancer progression and cardiovascular development.
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