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Description
Biotin Mouse Anti-Human B7-H4 Antibody (S-3024)Product Specification Host Mouse Antigen B7 H4 Synonyms V set domain containing T cell activation inhibitor 1; B7 homolog 4 (B7 H4); B7h. 5; Immune costimulatory protein B7 H4; Protein B7S1; T cell costimulatory molecule B7x; B7H4; VTCN1 Location Cell membrane Accession Q7Z7D3 Clone Number S 3024 Antibody Type Mouse mAb Isotype IgG1,k Application FCM Reactivity Hu Positive Sample SK BR 3 Purification Protein G Concentration 0. 2 mg ml Conjugation
Product Specification
| Host | Mouse |
| Antigen | B7-H4 |
| Synonyms | V-set domain-containing T-cell activation inhibitor 1; B7 homolog 4 (B7-H4); B7h.5; Immune costimulatory protein B7-H4; Protein B7S1; T-cell costimulatory molecule B7x; B7H4; VTCN1 |
| Location | Cell membrane |
| Accession | Q7Z7D3 |
| Clone Number | S-3024 |
| Antibody Type | Mouse mAb |
| Isotype | IgG1,k |
| Application | FCM |
| Reactivity | Hu |
| Positive Sample | SK-BR-3 |
| Purification | Protein G |
| Concentration | 0.2 mg/ml |
| Conjugation | Biotin |
| Physical Appearance | Liquid |
| Storage Buffer | PBS pH7.4, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Dilution
| application | dilution | species |
| FCM | 5μl per million cells in 100μl volume | Hu |
Background
B7-H4, also known as VTCN1 or B7x, is a ~50 kDa type-I trans-membrane glycoprotein of the B7 immunoglobulin superfamily that consists of an extracellular IgV-IgC domain pair, a single trans-membrane segment and a short cytoplasmic tail; it is expressed inducibly on antigen-presenting cells and constitutively on many epithelial cancers, where it acts as an immune-checkpoint ligand by binding an as-yet-unidentified receptor on activated CD4⁺ and CD8⁺ T cells, thereby arresting the cell cycle in G0/G1, suppressing IL-2 production and proliferation, and enabling tumours to evade immunity, making it an emerging target for cancer immunotherapy.
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