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Description
INSM1 Recombinant Rabbit mAb (SDT-3165-72)Product Specification Host Rabbit Antigen INSM1 Synonyms Insulinoma associated protein 1; Zinc finger protein IA 1; IA1 Immunogen Synthetic Peptide Location Nucleus Accession Q01101 Clone Number SDT 3165 72 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P Reactivity Hu, Ms, Rt Positive Sample NCI H69, Y79, TC 6, PC 12 Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS,
Product Specification
| Host | Rabbit |
| Antigen | INSM1 |
| Synonyms | Insulinoma-associated protein 1; Zinc finger protein IA-1; IA1 |
| Immunogen | Synthetic Peptide |
| Location | Nucleus |
| Accession | Q01101 |
| Clone Number | SDT-3165-72 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P |
| Reactivity | Hu, Ms, Rt |
| Positive Sample | NCI-H69, Y79, β-TC-6, PC-12 |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu, Ms, Rt |
| IHC-P | 1:1000 | Hu |
Background
INSM1 (Insulinoma-associated 1) is a 58 kDa zinc-finger transcription factor transiently expressed during embryogenesis in neuroendocrine tissues, pancreas and nervous system, where it drives differentiation by repressing progenitor genes such as Ascl1 and NeuroD/β2 while promoting cell-cycle exit, and later in life its re-expression in neuroendocrine tumors sustains oncogenesis through feed-forward loops that stabilize MYC proteins and activate PI3K/AKT signaling.
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