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Description
SORT1 Recombinant Rabbit mAb (S-2233-47)Product Specification Host Rabbit Antigen SORT1 Synonyms Sortilin; 100 kDa NT receptor; Glycoprotein 95 (Gp95); Neurotensin receptor 3 (NT3; NTR3) Immunogen Recombinant Protein Location Cell membrane, Endoplasmic reticulum membrane, Nucleus membrane Accession Q99523 Clone Number S 2233 47 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P, ICC Reactivity Hu, Ms, Rt Positive Sample SH SY5Y, PANC 1, SK BR 3, Neruo 2a, rat brain Purification
Product Specification
| Host | Rabbit |
| Antigen | SORT1 |
| Synonyms | Sortilin; 100 kDa NT receptor; Glycoprotein 95 (Gp95); Neurotensin receptor 3 (NT3; NTR3) |
| Immunogen | Recombinant Protein |
| Location | Cell membrane, Endoplasmic reticulum membrane, Nucleus membrane |
| Accession | Q99523 |
| Clone Number | S-2233-47 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P, ICC |
| Reactivity | Hu, Ms, Rt |
| Positive Sample | SH-SY5Y, PANC-1, SK-BR-3, Neruo-2a, rat brain |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20°C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu, Ms, Rt |
| IHC-P | 1:1000 | Hu, Ms, Rt |
| ICC | 1:500 | Ms |
Background
Sortilin 1 (SORT1) is a type I transmembrane glycoprotein encoded by the SORT1 gene, belonging to the vacuolar protein sorting 10 protein (Vps10p) family of sorting receptors. It is ubiquitously expressed in many tissues, with particularly high levels in the central nervous system. SORT1 plays a critical role in intracellular protein transport between the Golgi apparatus, endosomes, lysosomes, and plasma membrane, and is involved in various biological processes such as glucose and lipid metabolism, neural development, and cell death. The Vps10p domain of SORT1 forms a ten-bladed beta-propeller structure with multiple ligand binding sites, allowing it to bind over 50 proteins. SORT1 is also implicated in several diseases, including hypertension, atherosclerosis, coronary artery disease, Alzheimer’s disease, and cancer. Additionally, the SORT1 gene is located at a locus strongly associated with LDL cholesterol levels in genome-wide association studies.
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