SKU: 83745286630

BID Protein, Huamn

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Description

BID Protein, HuamnProduct Specification Species Human Synonyms BH3 Interacting Domain Death Agonist; p22 BID; BID Accession P55957 Amino Acid Sequence Met1 Asp195 Expression System E. coli Molecular Weight 21. 99 KDa Purity >95% by SDS PAGE Endotoxin <1EU g Conjugation Unconjugated Tag No Tag Physical Appearance Liquid Storage Buffer 20mM PB, 100mM KCl, pH 7. 4. Stability & Storage Store at 70C, stable for 6 months after receipt. Store at 70C, stable for 3 months under

Product Specification


Species Human
Synonyms BH3-Interacting Domain Death Agonist; p22 BID; BID
Accession P55957
Amino Acid Sequence

Met1-Asp195

Expression System E.coli
Molecular Weight

21.99 KDa

Purity

>95% by SDS-PAGE

Endotoxin <1EU/μg
Conjugation Unconjugated
Tag No Tag
Physical Appearance Liquid
Storage Buffer 20mM PB, 100mM KCl, pH 7.4.
Stability & Storage
  • Store at ≤-70°C, stable for 6 months after receipt.
  • Store at ≤-70°C, stable for 3 months under sterile conditions after opening.
  • Please minimize freeze-thaw cycles.


Background

BH3-Interacting Domain Death Agonist (BID) is a member of the Bcl-2 protein family which regulates outer mitochondrial membrane permeability. BID is a pro-apoptotic member that causes cytochrome c to be released from the mitochondria intermembrane space into the cytosol. Interaction of Bid with Bak causes altered mitochondrial membrane permeability. BID contains only the BH3 domain, which is required for its interaction with the Bcl-2 family proteins and for its pro-death activity. BID is susceptible to proteolytic cleavage by caspases, calpains, Granzyme B and cathepsins. It is an integrating key regulator of the intrinsic death pathway that amplifies caspase-dependent and caspase-independent execution of neuronal apoptosis. Therefore pharmacological inhibition of BID provides a promising therapeutic strategy in neurological diseases where programmed cell death is prominent, and also offer a new strategy for the treatment of acute renal failure associated with ischemia-reperfusion. BID receives direct inputs from a key regulator of the cell cycle arrest/DNA repair machinery (ATM), and therefore is an excellent candidate to coordinate genotoxic stress responses and apoptotic cell death. BID is a novel pro-apoptosis Bcl-2 family protein that is activated by caspase 8 in response to Fas/TNF-R1 death receptor signals. Deletion of BID inhibits carcinogenesis in the liver, although this genetic alteration promotes tumorigenesis in the myeloid cells. This is likely related to the function of BID to promote cell cycle progression into S phase. BID could be also involved in the maintenance of genomic stability by engaging at mitosis checkpoint.

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Exchange/Return Notes
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SKU: 83745286630

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NY2CO
Lexington, US
★★★★★ 5
Save money by installing yourself
Size: 9.5" x 10.9" x 2.1"
Good price and easy to install in a 2019 Honda CRV. Instructions can be found on YouTube. Much less expensive than having a service center install them.
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Reviewed in the United States on February 14, 2026
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Customer Review
San Leandro, US
★★★★★ 4
Always fits and is easy to install
Size: 9.5" x 10.9" x 2.1"
We've bought these for years and they always fit and are easy to install. Easy to see when they are dirty and need to throw away. Embarrassed that we let the car dealership do it for so long. We set on six-month subscribe and save so that we know when to replace it - change it whenever it shows up!
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Reviewed in the United States on September 13, 2023
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Verified Purchase
Randy Shiverdecker
Natrona Heights, US
★★★★★ 5
Better than I expected.
Size: 9.5" x 10.9" x 2.1"
Fits perfectly. Easy to install. As good of quality as the original equipment filter.
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Reviewed in the United States on January 9, 2026
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Victor Escobar
Omaha, US
★★★★★ 5
Great
Size: 9.5" x 10.9" x 2.1"
Excellent product! My car really needed it. Super fast delivery and the best price. I'm super happy with this product.
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Reviewed in the United States on November 12, 2025
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Gladys
Waukegan, US
★★★★★ 5
Honda crv filter
Size: 9.5" x 10.9" x 2.1"
Good cabin filter for my 2019 Honda crv
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Reviewed in the United States on May 11, 2026

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