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Description
PE-Cy7 Armenian hamster Anti-Mouse CD11c Antibody (S-R518)Product Specification Host Armenian hamster Antigen CD11c Synonyms Integrin alpha X; CD11 antigen like family member C; Leukocyte adhesion glycoprotein p150,95 alpha chain; Leukocyte adhesion receptor p150,95; Itgax Location Membrane Accession Q9QXH4 Clone Number S R518 Antibody Type Recombinant mAb Isotype IgG Application FCM Reactivity Ms Positive Sample BALB c mouse splenocytes Purification Protein G Concentration 0. 2 mg ml Conjugation PE Cy7
Product Specification
| Host | Armenian hamster |
| Antigen | CD11c |
| Synonyms | Integrin alpha-X; CD11 antigen-like family member C; Leukocyte adhesion glycoprotein p150,95 alpha chain; Leukocyte adhesion receptor p150,95; Itgax |
| Location | Membrane |
| Accession | Q9QXH4 |
| Clone Number | S-R518 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | FCM |
| Reactivity | Ms |
| Positive Sample | BALB/c mouse splenocytes |
| Purification | Protein G |
| Concentration | 0.2 mg/ml |
| Conjugation | PE-Cy7 |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 1% BSA, 0.3% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Dilution
| application | dilution | species |
| FCM | 1.25μl per million cells in 100μl volume | Ms |
Background
CD11c, also known as integrin alpha X (ITGAX), is a ~150 kDa type I transmembrane glycoprotein that pairs non-covalently with the 95 kDa beta2 integrin CD18 to form the αXβ2 heterodimer (complement receptor 4, CR4), which mediates cell adhesion, migration, and phagocytosis by binding diverse ligands such as iC3b, fibrinogen, ICAMs, and denatured proteins; it is predominantly expressed on myeloid dendritic cells, tissue macrophages, activated monocytes, and some B-cell subsets, serving as a classic marker for conventional dendritic cells in both mice and humans, and plays crucial roles in immune surveillance, antigen presentation, and inflammatory responses while also being implicated in autoimmune diseases and serving as a therapeutic target in cancer immunotherapy.
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