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Description
S-RMab® GST-π Recombinant Rabbit mAb (SDT-561-78)Product Specification Host Rabbit Antigen GST Synonyms Glutathione S Transferase Pi, GST pi, GST class pi, GSTP1 1, GST Immunogen Synthetic Peptide Location Cytoplasm, Nucleus Accession P09211 Clone Number SDT 561 78 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P, ICC, ICFCM Reactivity Hu, Ms, Rt Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS, 40% Glycerol, 0.
Product Specification
| Host | Rabbit |
| Antigen | GST-π |
| Synonyms | Glutathione S-Transferase Pi, GST-pi, GST class-pi, GSTP1-1, GST π |
| Immunogen | Synthetic Peptide |
| Location | Cytoplasm, Nucleus |
| Accession | P09211 |
| Clone Number | SDT-561-78 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P, ICC, ICFCM |
| Reactivity | Hu, Ms, Rt |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05%BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | null |
| IHC | 1:1000 | null |
| ICC | 1:100 | null |
| ICFCM | 1:500 | null |
Background
Glutathione S-Transferases (GSTs) are members of the phase II detoxification enzyme family that conjugate glutathione to various electrophilic compounds, including metabolites generated by oxidative processes in the body, environmental toxins or carcinogens, and anti-cancer drugs. GSTP1 is a cytosolic protein that belongs to pi class of the GST superfamily. It is crystallized as a homodimer, but also exists in solution as an equilibrium mixture of monomer and dimer, depending on the protein concentration. Human GSTP1 is present at elevated levels in many tumor cells, and has unique properties as a cancer marker. Genetic polymorphisms and expression patterns of GSTP1 have been associated with a variety of effects on human cancer, anti-cancer drug resistance, and asthma. In addition to its role as a drug-metabolizing enzyme, GSTP1 has ligand binding properties and regulates kinase signaling pathways through protein-protein interactions.
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Exchange/Return Notes
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