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Description
CGRP Recombinant Rabbit mAb (SDT-2490-74)Product Specification Host Rabbit Antigen CGRP Synonyms Calcitonin gene related peptide 1; CGRP1 Immunogen Synthetic Peptide Accession P06881 Clone Number SDT 2490 74 Antibody Type Recombinant mAb Isotype IgG Application Sandwich ELISA Reactivity Hu Cross Reactivity It reacts with both CGRP and CGRP Purification Protein A Concentration 2 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS pH7. 4, 0. 03% Proclin 300 Stability &
Product Specification
| Host | Rabbit |
| Antigen | CGRP |
| Synonyms | Calcitonin gene-related peptide 1; CGRP1 |
| Immunogen | Synthetic Peptide |
| Accession | P06881 |
| Clone Number | SDT-2490-74 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | Sandwich ELISA |
| Reactivity | Hu |
| Cross Reactivity | It reacts with both α-CGRP and β-CGRP |
| Purification | Protein A |
| Concentration | 2 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS pH7.4, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt, 2 to 8 °C as supplied |
Background
CGRP (calcitonin gene-related peptide) is a 37-amino-acid neuropeptide produced by tissue-specific splicing of the CALCA gene in primary afferent sensory neurons and central neurons; it signals through a heterodimeric receptor composed of the G-protein-coupled receptor CALCRL and the accessory protein RAMP1, potently dilating cerebral and dermal vasculature, modulating nociceptive transmission, and mediating neuro-inflammatory responses, making it a key target for monoclonal antibodies and small-molecule antagonists in the prevention of migraine and the treatment of cluster headache.
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