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Description
PHOX2B Recombinant Rabbit mAb,PBS Only (SDT-1142-21)Product Specification Host Rabbit Synonyms Paired mesoderm homeobox protein 2B, Neuroblastoma Phox (NBPhox), PHOX2B homeodomain protein, Paired like homeobox 2B, PMX2B Immunogen Synthetic Peptide Location Nucleus Accession Q99453 Clone Number SDT 1142 21 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P Reactivity Hu, Ms, Rt Purification Protein A Concentration 1 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer
Product Specification
| Host | Rabbit |
| Synonyms | Paired mesoderm homeobox protein 2B, Neuroblastoma Phox (NBPhox), PHOX2B homeodomain protein, Paired-like homeobox 2B, PMX2B |
| Immunogen | Synthetic Peptide |
| Location | Nucleus |
| Accession | Q99453 |
| Clone Number | SDT-1142-21 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P |
| Reactivity | Hu, Ms, Rt |
| Purification | Protein A |
| Concentration | 1 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS |
| Stability & Storage | 12 months from date of receipt / reconstitution, 4 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | |
| IHC-P | 1:200-1:500 |
Background
PHOX2B is a homeodomain transcription factor that is mainly expressed in neuronal cells of the peripheral autonomic nervous system, and plays a key role in the differentiation of neurons and chromaffin cells, in particular. PHOX2B has high sensitivity and specificity in neuroblastoma tissues. In addition, it is directly related to autonomic nervous system diseases that may occur with neuroblastoma (such as congenital megacolon and congenital central hypoventilation syndrome).
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