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Description
APC Mouse Anti-Human CD191 Antibody (S-3286)Product Specification Host Mouse Antigen CD191 Synonyms C C chemokine receptor type 1; C C CKR 1; CC CKR 1; CCR 1; CCR1; HM145; LD78 receptor; Macrophage inflammatory protein 1 alpha receptor (MIP 1alpha R); RANTES R; CMKBR1; CMKR1; SCYAR1 Location Cell membrane Accession P32246 Clone Number S 3286 Antibody Type Mouse mAb Isotype IgG1,k Application FCM Reactivity Hu Positive Sample Human PBMC Purification Protein G Concentration 0. 2 mg ml Conjugation
Product Specification
| Host | Mouse |
| Antigen | CD191 |
| Synonyms | C-C chemokine receptor type 1; C-C CKR-1; CC-CKR-1; CCR-1; CCR1; HM145; LD78 receptor; Macrophage inflammatory protein 1-alpha receptor (MIP-1alpha-R); RANTES-R; CMKBR1; CMKR1; SCYAR1 |
| Location | Cell membrane |
| Accession | P32246 |
| Clone Number | S-3286 |
| Antibody Type | Mouse mAb |
| Isotype | IgG1,k |
| Application | FCM |
| Reactivity | Hu |
| Positive Sample | Human PBMC |
| Purification | Protein G |
| Concentration | 0.2 mg/ml |
| Conjugation | APC |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 1% BSA, 0.3% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Dilution
| application | dilution | species |
| FCM | 1.25μl per million cells in 100μl volume | Hu |
Background
CD191 (officially designated CD191, also termed C-C chemokine receptor type 1, CCR1) is a 41 kDa seven-transmembrane G-protein-coupled receptor encoded by the CCR1 gene on chromosome 3p; it is predominantly expressed on monocytes, granulocytes, and a subset of T cells, where it binds the CC chemokines CCL3 (MIP-1α), CCL5 (RANTES), CCL7 (MCP-3) and CCL23 (MPIF-1) to trigger intracellular signaling that mediates chemotactic recruitment of effector leukocytes to inflammatory sites, thereby playing key roles in host defense against infection, regulation of inflammatory responses, and susceptibility to viral and parasitic pathogens.
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