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Description
Alpha B Crystallin Recombinant Rabbit mAb (S-R216)Product Specification Host Rabbit Antigen Alpha B Crystallin Synonyms Alpha crystallin B chain, Heat shock protein beta 5 (HspB5), Renal carcinoma antigen NY REN 27, Rosenthal fiber component, CRYAB, CRYA2 Location Cytoplasm, Nucleus, Secreted Accession P02511 Clone Number S R216 Antibody Type Recombinant mAb Application IHC P, ICC, ICFCM, IF Reactivity Hu, Ms, Rt Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated Physical
Product Specification
| Host | Rabbit |
| Antigen | Alpha B Crystallin |
| Synonyms | Alpha-crystallin B chain, Heat shock protein beta-5 (HspB5), Renal carcinoma antigen NY-REN-27, Rosenthal fiber component, CRYAB, CRYA2 |
| Location | Cytoplasm, Nucleus, Secreted |
| Accession | P02511 |
| Clone Number | S-R216 |
| Antibody Type | Recombinant mAb |
| Application | IHC-P, ICC, ICFCM, IF |
| Reactivity | Hu, Ms, Rt |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05%BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| IHC | 1:2000 | null |
| ICC | 1:100 | null |
| ICFCM | 1:50 | null |
| IF | 1:500 | null |
Background
Alpha-crystallin B chain is a protein that in humans is encoded by the CRYAB gene. It is part of the small heat shock protein family and functions as molecular chaperone that primarily binds misfolded proteins to prevent protein aggregation, as well as inhibit apoptosis and contribute to intracellular architecture. Mutations in CRYAB cause different cardiomyopathies, skeletal myopathies mainly myofibrillar myopathy, and also cataracts. In addition, defects in this gene/protein have been associated with cancer and neurodegenerative diseases such as Alzheimer's disease and Parkinson's disease.
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