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Description
KLF5 Recombinant Rabbit mAb (S-3200-113)Product Specification Host Rabbit Antigen KLF5 Synonyms Krueppel like factor 5; Basic transcription element binding protein 2 (BTE binding protein 2); Colon krueppel like factor; GC box binding protein 2; Intestinal enriched krueppel like factor; Transcription factor BTEB2; BTEB2; CKLF; IKLF Immunogen Recombinant Protein Location Nucleus Accession Q13887 Clone Number S 3200 113 Antibody Type Recombinant mAb Isotype IgG Application WB Reactivity Hu
Product Specification
| Host | Rabbit |
| Antigen | KLF5 |
| Synonyms | Krueppel-like factor 5; Basic transcription element-binding protein 2 (BTE-binding protein 2); Colon krueppel-like factor; GC-box-binding protein 2; Intestinal-enriched krueppel-like factor; Transcription factor BTEB2; BTEB2; CKLF; IKLF |
| Immunogen | Recombinant Protein |
| Location | Nucleus |
| Accession | Q13887 |
| Clone Number | S-3200-113 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB |
| Reactivity | Hu |
| Positive Sample | COLO 205, HeLa |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu |
Background
KLF5 (Krüppel-like factor 5) is a zinc finger transcription factor belonging to the Krüppel-like factor family, characterized by three highly conserved Cys2His2 zinc finger domains at its C-terminus that enable sequence-specific DNA binding to GC-rich elements in target gene promoters. This multifunctional protein plays pivotal roles in regulating cell proliferation, differentiation, apoptosis, and inflammation across various tissues, with its activity context-dependently acting as either an oncogene or tumor suppressor depending on the cellular environment and post-translational modifications. KLF5 is particularly significant in epithelial biology, where it maintains intestinal epithelial homeostasis, promotes vascular smooth muscle cell differentiation, and regulates adipogenesis. The protein undergoes extensive post-translational regulation, including acetylation, phosphorylation, ubiquitination, and SUMOylation, which modulate its stability, subcellular localization, and transcriptional activity. In cancer biology, KLF5 demonstrates complex dual functionality: it can promote tumorigenesis in prostate and breast cancers through activation of pro-survival genes, while exhibiting tumor-suppressive properties in colorectal and gastric cancers via regulation of cell cycle inhibitors like p21 and p27. Additionally, KLF5 serves as a critical mediator in multiple signaling pathways, including TGF-β, Wnt/β-catenin, and MAPK cascades, and has emerged as a potential therapeutic target and biomarker for various malignancies and inflammatory disorders, with ongoing research exploring its mechanistic roles in metabolic diseases and tissue regeneration.
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