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Description
AITRL Protein, MouseProduct Specification Species Mouse Antigen AITRL Synonyms AITRL, Activation induced TNFR member Ligand, TNFSF18, GITRL,TL 6 Accession Q7TS55 Amino Acid Sequence Thr47 Ser173 Expression System E. coli Molecular Weight 14. 5kD Purity 95% by SDS PAGE & RP HPLC Endotoxin <0. 1EU g Conjugation Unconjugated Tag No Tag Physical Appearance Lyophilized Powder Storage Buffer 20mM PB, 150mM NaCl, pH6. 0 Reconstitution Reconstitute at 0. 1 1 mg ml according to
Product Specification
| Species | Mouse |
| Antigen | AITRL |
| Synonyms | AITRL, Activation-induced TNFR member Ligand, TNFSF18, GITRL,TL-6 |
| Accession | Q7TS55 |
| Amino Acid Sequence | Thr47-Ser173 |
| Expression System | E.coli |
| Molecular Weight | 14.5kD |
| Purity | ＞95% by SDS-PAGE & RP-HPLC |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | No Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | 20mM PB, 150mM NaCl, pH6.0 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference | 1. Li L, Wen W, Jia R, Li Y, Liu X, Sun X, Li Z. GITRL is associated with increased autoantibody production in patients with rheumatoid arthritis. Clin Rheumatol. 2016 Sep;35(9):2195-202. Epub 2016 Apr 21. |
Background
Activation-Inducible TNF-Related Ligand (AITRL), also known as Glucocorticoid-induced tumor necrosis factor receptor (TNFR) family-related protein (GITR), is a type I transmembrane protein that belongs to the TNF receptor superfamily. This cytokine is a ligand for receptor TNFRSF18/AITR/GITR. It has been shown to modulate T lymphocyte survival in peripheral tissues. This cytokine is also found to be expressed in endothelial cells, and is thought to be important for interaction between T lymphocytes and endothelial cells. GITR-GITRL cross-linking costimulated native and activated T cells and resulted in MAPK activation. Researches have indicated that GITRL could promote Th17 cell differentiation by p38 MAPK and STAT3 signaling in autoimmune arthritis.
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