Pay in installments of $21.25 with
,
and
Shipping Estimate
USA
- USA
- CAN
- USA
- CAN
Ships within 48 hours · Estimated delivery Aug 29 - Sep 3
Promo Codes Available:
For Your Every Summer RSVP, with Code: SUMMER15
Description
Biotin Rat Anti-Mouse CD43 Antibody (S-R588)Product Specification Host Rat Antigen CD43 Synonyms Leukosialin; B cell differentiation antigen LP 3; Leukocyte sialoglycoprotein; Lymphocyte antigen 48 (Ly 48); Sialophorin; Spn Location Membrane Accession P15702 Clone Number S R588 Antibody Type Rat mAb Isotype IgG2a,k Application FCM Reactivity Ms Positive Sample C57BL 6 mouse splenocytes Purification Protein G Concentration 0. 2 mg ml Conjugation Biotin Physical Appearance Liquid Storage Buffer
Product Specification
| Host | Rat |
| Antigen | CD43 |
| Synonyms | Leukosialin; B-cell differentiation antigen LP-3; Leukocyte sialoglycoprotein; Lymphocyte antigen 48 (Ly-48); Sialophorin; Spn |
| Location | Membrane |
| Accession | P15702 |
| Clone Number | S-R588 |
| Antibody Type | Rat mAb |
| Isotype | IgG2a,k |
| Application | FCM |
| Reactivity | Ms |
| Positive Sample | C57BL/6 mouse splenocytes |
| Purification | Protein G |
| Concentration | 0.2 mg/ml |
| Conjugation | Biotin |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 1% BSA, 0.3% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Dilution
| application | dilution | species |
| FCM | 5μl per million cells in 100μl volume | Ms |
Background
CD43, also known as leukosialin or sialophorin, is a highly glycosylated type I transmembrane protein predominantly expressed on most hematopoietic cells, with the exception of resting B cells and erythrocytes. It belongs to the sialomucin superfamily and is one of the largest cell-surface molecules, extending approximately 45 nm from the cell surface. The protein consists of a heavily glycosylated extracellular region, a transmembrane helix, and a small cytoplasmic region. CD43 plays a significant role in immune function, particularly in T-cell activation and proliferation, and is involved in both cell adhesion and cell activation processes. It is actively excluded from the immunological synapse during T-cell activation, a process that requires interactions with ezrin-radixin-moesin (ERM) proteins. Additionally, CD43 has been shown to regulate T helper type 2 differentiation and can act as a co-stimulatory molecule for T-cell activation.
Shipping Notes
- Free Standard Shipping on $100+ Orders to the USA.
- Except Preorder products are shipped in 48 hours.
- Delivery to the USA:
- Standard Shipping : 3-10 business days
- If time is of the essence, please consider selecting expedited delivery for faster service.
Exchange/Return Notes
- We offer a 30-day return/exchange service after receiving.
- Final sale items are not eligible for returns or exchanges.
- To process your return/exchange, please contact us at [email protected]
- Please click here for more details>>> Return & Exchange Policy