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Description
B7-H3 Recombinant Rabbit mAb,PBS Only (SDT-249-26)Product Specification Host Rabbit Antigen B7 H3 Synonyms CD276 antigen, 4Ig B7 H3, B7 homolog 3 (B7 H3), Costimulatory molecule, CD276 Immunogen Synthetic Peptide Location Membrane Accession Q5ZPR3 Clone Number SDT 249 26 Antibody Type Recombinant mAb Application WB, IHC P, ICC, IP, IF, ICFCM Reactivity Hu Purification Protein A Concentration 1 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS Stability & Storage 12 months
Product Specification
| Host | Rabbit |
| Antigen | B7-H3 |
| Synonyms | CD276 antigen, 4Ig-B7-H3, B7 homolog 3 (B7-H3), Costimulatory molecule, CD276 |
| Immunogen | Synthetic Peptide |
| Location | Membrane |
| Accession | Q5ZPR3 |
| Clone Number | SDT-249-26 |
| Antibody Type | Recombinant mAb |
| Application | WB, IHC-P, ICC, IP, IF, ICFCM |
| Reactivity | Hu |
| Purification | Protein A |
| Concentration | 1 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS |
| Stability & Storage | 12 months from date of receipt / reconstitution, 4 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | |
| IP | 1:50 | |
| IHC | 1:2000 | |
| ICFCM | 1:500 | |
| ICC | 1:500 | |
| IF | 1:1000 |
Background
B7-H3 is a 316 amino acid-long type I transmembrane protein, existing in two isoforms determined by its extracellular domain. In humans it consists of one pair (2Ig-B7-H3) or two identical pairs (4Ig-B7-H3) due to exon duplication. B7-H3 mRNA is expressed in most normal tissues. In contrast, B7-H3 protein has a very limited expression on normal tissues because of its post-transcriptional regulation by microRNAs. However, B7-H3 protein is expressed at high frequency on many different cancer types (60% of all cancers). In non-malignant tissues, B7-H3 has a predominantly inhibitory role in adaptive immunity, suppressing T cell activation and proliferation. In malignant tissues, B7-H3 is an immune checkpoint molecule that inhibits tumor antigen-specific immune responses. B7-H3 also possesses non-immunological pro-tumorigenic functions such as promoting migration, invasion, angiogenesis, chemoresistance, epithelial-to-mesenchymal transition, and affecting tumor cell metabolism.
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