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Description
CD27 Mouse mAb (S-568-2)Product Specification Host Mouse Antigen CD27 Synonyms CD27L receptor, T cell activation antigen CD27, T14, Tumor necrosis factor receptor superfamily member 7, TNFRSF7 Immunogen Recombinant Protein Location Membrane Accession P26842 Clone Number S 568 2 Antibody Type Mouse mAb Isotype IgG1,k Application ICC, FCM Reactivity Hu Purification Protein G Concentration 2 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS, 40%
Product Specification
| Host | Mouse |
| Antigen | CD27 |
| Synonyms | CD27L receptor, T-cell activation antigen CD27, T14, Tumor necrosis factor receptor superfamily member 7, TNFRSF7 |
| Immunogen | Recombinant Protein |
| Location | Membrane |
| Accession | P26842 |
| Clone Number | S-568-2 |
| Antibody Type | Mouse mAb |
| Isotype | IgG1,k |
| Application | ICC, FCM |
| Reactivity | Hu |
| Purification | Protein G |
| Concentration | 2 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05%BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| FCM | 1:2000 | |
| ICC | 1:500 |
Background
CD27 is a member of the TNF-receptor superfamily. This receptor is required for generation and long-term maintenance of T cell immunity. It binds to ligand CD70, and plays a key role in regulating B-cell activation and immunoglobulin synthesis. When CD27 binds CD70, a signaling cascade leads to the differentiation and clonal expansion of T cells. The cascade also results in improved survival and memory of cytotoxic T cells and increased production of certain cytokines. It is currently of interest to immunologists as a co-stimulatory immune checkpoint molecule, and is the target of an anti-cancer drug in clinical trials.
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