SKU: 73180361201

APC Mouse Anti-Human CD18 Antibody (S-R487)

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Description

APC Mouse Anti-Human CD18 Antibody (S-R487)Product Specification Host Mouse Antigen CD18 Synonyms Integrin beta 2; Cell surface adhesion glycoproteins LFA 1 CR3 p150,95 subunit beta; Complement receptor C3 subunit beta; MFI7; ITGB2 Location Cell membrane Accession P05107 Clone Number S R487 Antibody Type Mouse mAb Isotype IgG1,k Application FCM Reactivity Hu Positive Sample Human PBMC Purification Protein G Concentration 0. 2 mg ml Conjugation APC Physical Appearance Liquid Storage Buffer PBS,

Product Specification


Host Mouse
Antigen CD18
Synonyms Integrin beta-2; Cell surface adhesion glycoproteins LFA-1/CR3/p150,95 subunit beta; Complement receptor C3 subunit beta; MFI7; ITGB2
Location Cell membrane
Accession P05107
Clone Number S-R487
Antibody Type Mouse mAb
Isotype IgG1,k
Application FCM
Reactivity Hu
Positive Sample Human PBMC
Purification Protein G
Concentration 0.2 mg/ml
Conjugation APC
Physical Appearance Liquid
Storage Buffer

PBS, 1% BSA, 0.3% Proclin 300
Stability & Storage

12 months from date of receipt / reconstitution, 2 to 8 °C as supplied

Dilution


application dilution species
FCM 1.25μl per million cells in 100μl volume Hu

Background

CD18, also known as integrin β2, is a 95 kDa glycoprotein that is a crucial component of several β2 integrins. These integrins are heterodimeric type I transmembrane proteins composed of a variable alpha chain (CD11a-d) and the common beta chain CD18. The CD18 protein is encoded by the ITGB2 gene in humans. It plays a significant role in cellular adhesion and immune responses. When CD18 binds with different alpha chains, it forms various heterodimers such as lymphocyte function-associated antigen-1 (LFA-1) with CD11a, and Macrophage-1 antigen receptor (Mac-1) with CD11b. These heterodimers are involved in processes like leukocyte adhesion to endothelial cells, phagocytosis, and immune cell activation. Deficiencies in CD18 expression can lead to adhesion defects in white blood cells, impairing the immune system's ability to fight infections.

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SKU: 73180361201

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4.5 ★★★★★
Based on 16 reviews
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Product Reviews
D
Verified Purchase
Deholle
Phoenix, US
★★★★★ 4
Tuffy Desert Phrog vs Lola
Color: Green Leaping Phrog, Color: Green Leaping Phrog
Just a little background about my dog. Lola is a 5 year old corgi-terrier mix with jaws of steal. Lesser stuffed toys have met death in under 5 minutes. Tennis balls last less than a day. Rope toys that do not have frayed ends might possibly last a week (frayed ends never stand a chance). The only toys that she has not managed to destroy are her Kong, a Kong bone, and a racquet ball. I figured I would document the life span of Phrog (Tuffy Scale: 9) before making my final judgement on it’s durability. Day 1 - Phrog Arrives! Lola was very excited about the arrival of Phrog and immediately went into destruction mode. Phrog did sustain a little damage before we were able to bribe her to drop Phrog and get her understand that he was more fun to play fetch with than to mutilate. The white you see in the picture is not stuffing, but the second layer of defense for the toy. The fact that my living room is not full of stuffing and I didn’t have to pry a squeaker out of my dog’s mouth, I’d say Phrog wins the Day 1 challenge. Day 9 - Phrog has sustained a little more damage, but not anything life threatening. His side wound is a little bit larger and one of his eyes is half ripped off. For safety reasons, I am going to finish removing the damaged eye and some loose thread from various places. Other than that, Phrog is still holding up and holds top toy spot. I have also found him very useful for dealing with anxiety; the squeaker can often distract her from her stressors and Phrog takes the abuse of her frustrations. Day 16 - Phrog is starting to show signs of mortal wounds. Lola has made it through the thicker layer around his arm and I can see the stuffing. It is only a matter of time before gets all the way through. Day 60 - Phrog still lives!!! I have done some surgery on Phrog to reinforce the fabric around his arms, but Franken-Phrog is still the favorite of all of the toys. She will even get brave enough to rescue Phrog from the evil vacuum when he is kidnapped and tortured. I am thinking about purchasing Phrog II for the inevitable day when Phrog goes off to the pet toyland in the sky, but for now, there is only one Phrog for Lola.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on July 6, 2018
M
Verified Purchase
michael parsley
Carnegie, US
★★★★★ 5
Super tough
Color: Red Warthog
My dogs love these toys!!!
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on February 10, 2026
A
Verified Purchase
Amazon Customer
New York, US
★★★★★ 5
Long lasting play toy!
Color: Multicolor
Tuffy toys in general are great and they are a pretty good deal on Amazon. They are not indestructible, and if your dogs use them as chew toys they will eventually break through. My dogs have had this Armadillo since Christmas (and they do chew on it some) and the only thing missing is an ear. They like to play tug-of-war with it a lot. This is a bigger toy, but even my forty pound dog plays with it. I would not recommend this toy for dogs smaller than Border Collie size. You can make these Tuffy toys last longer if you don't allow your dogs to chew them--when your dogs starts chewing on non-chew toys trade them for a chew toy and when you catch your dog chewing on a chew-approved toy reward them for chewing. Eventually your dog will catch on and realize that if they want to chew there are certain toys that are allowed for that. In addition to being a great play toy this is a pretty cute toy too!
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Reviewed in the United States on June 30, 2015
A
Verified Purchase
Amazon Customer
Lexington, US
★★★★★ 1
Not Tuff
Color: Black Yellow Phrog, Color: Black Yellow Phrog
Absolutely terrible and not “tuff” at all. My chocolate lab had this thing destroyed in less than two hours. I would not recommend these for the price.
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Reviewed in the United States on April 11, 2026
C
Verified Purchase
Carrie Ann Moore
Lowell, US
★★★★★ 3
Cute but Not Durable
Color: 2PK Green Leaping Phrog
⭐️⭐️⭐️⭐️ Cute but Not Durable Super cute toy—my dogs loved it right away! Unfortunately, they chewed the head off within a few hours. I ordered a second one because they were so into it, but the same thing happened again. I won’t be ordering a third, but they still play with their two headless frogs. So while it’s not the most durable, it definitely kept them entertained!
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Reviewed in the United States on June 9, 2025

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