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Description
FACL4 Rabbit Polyclonal AntibodyProduct Specification Host Rabbit Antigen FACL4 Synonyms Long chain fatty acid CoA ligase 4; Arachidonate CoA ligase; Long chain acyl CoA synthetase 4 (LACS 4); ACS4; LACS4; ACSL4 Immunogen Synthetic Peptide Location Cell membrane, Endoplasmic reticulum membrane, Mitochondrion outer membrane Accession O60488 Antibody Type Polyclonal antibody Isotype IgG Application WB, IHC P Reactivity Hu Positive Sample MCF7, T 47D, HeLa, 293T Purification Immunogen
Product Specification
| Host | Rabbit |
| Antigen | FACL4 |
| Synonyms | Long-chain-fatty-acid--CoA ligase 4; Arachidonate--CoA ligase; Long-chain acyl-CoA synthetase 4 (LACS 4); ACS4; LACS4; ACSL4 |
| Immunogen | Synthetic Peptide |
| Location | Cell membrane, Endoplasmic reticulum membrane, Mitochondrion outer membrane |
| Accession | O60488 |
| Antibody Type | Polyclonal antibody |
| Isotype | IgG |
| Application | WB, IHC-P |
| Reactivity | Hu |
| Positive Sample | MCF7, T-47D, HeLa, 293T |
| Purification | Immunogen Affinity |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu |
| IHC-P | 1:250 | Hu |
Background
FACL4 (Fatty Acid-CoA Ligase 4), also known as ACSL4, is an enzyme that belongs to the long-chain fatty-acid-CoA ligase family, encoded by the ACSL4 gene. This enzyme plays a crucial role in lipid metabolism by converting free long-chain fatty acids into fatty acyl-CoA esters, which are involved in various metabolic pathways including β-oxidation, glycerolipid synthesis, and protein acylation. FACL4 is unique in its preference for arachidonic acid (AA) as a substrate, and it helps regulate the levels of free AA in cells, which is known to induce apoptosis. The protein is highly expressed in tissues such as the brain, testis, ovary, spleen, and adrenal cortex, and its absence may contribute to conditions like intellectual disability or Alport syndrome. Additionally, FACL4 has been implicated in cancer development, with studies showing its upregulation in colon adenocarcinoma and hepatocellular carcinoma, suggesting its potential involvement in tumorigenesis.
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