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Description
PYCR1 Rabbit Polyclonal AntibodyProduct Specification Host Rabbit Antigen PYCR1 Synonyms Pyrroline 5 carboxylate reductase 1, mitochondrial; P5C reductase 1; P5CR 1 Immunogen Synthetic Peptide Location Mitochondrion Accession P32322 Antibody Type Polyclonal antibody Isotype IgG Application WB, IHC P, ICC Reactivity Hu Positive Sample HeLa, HepG2, PANC 1, A549 Purification Immunogen Affinity Concentration 0. 5 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer
Product Specification
| Host | Rabbit |
| Antigen | PYCR1 |
| Synonyms | Pyrroline-5-carboxylate reductase 1, mitochondrial; P5C reductase 1; P5CR 1 |
| Immunogen | Synthetic Peptide |
| Location | Mitochondrion |
| Accession | P32322 |
| Antibody Type | Polyclonal antibody |
| Isotype | IgG |
| Application | WB, IHC-P, ICC |
| Reactivity | Hu |
| Positive Sample | HeLa, HepG2, PANC-1, A549 |
| Purification | Immunogen Affinity |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu |
| IHC-P | 1:200 | Hu |
| ICC | 1:500 | Hu |
Background
PYCR1（pyrroline-5-carboxylate reductase 1）is an enzyme encoded by the PYCR1 gene, located on human chromosome 17q25.3. It catalyzes the NAD(P)H-dependent conversion of pyrroline-5-carboxylate to proline, playing a crucial role in proline biosynthesis. PYCR1 is primarily localized in the mitochondria and forms homopolymers. This enzyme may also be involved in the generation of NADP(+) in certain cell types. PYCR1 is broadly expressed in various tissues, including the salivary gland and stomach. It has been implicated in multiple biological processes and diseases. For instance, PYCR1 is overexpressed in many cancers, promoting tumor growth, invasion, and metastasis by supporting proline synthesis and activating various signaling pathways. In addition, it is involved in the regulation of cell proliferation and drug resistance in colorectal cancer through the STAT3-mediated p38 MAPK and NF-κB signaling pathways.
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