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Description
TECK/CCL25 Protein, HumanProduct Specification Species Human Synonyms Thymus Expressed Chemokine, CCL25 Accession O15444 1 Amino Acid Sequence Gln24 Leu150 Expression System E. coli Molecular Weight 16kDa Purity >95% by SDS PAGE Endotoxin <0. 1EU g Conjugation Unconjugated Tag No Tag Physical Appearance Lyophilized Powder Storage Buffer PBS, pH7. 4 Reconstitution Reconstitute at 0. 1 1 mg ml according to the size in ultrapure water after rapid centrifugation. Stability &
Product Specification
| Species | Human |
| Synonyms | Thymus Expressed Chemokine, CCL25 |
| Accession | O15444-1 |
| Amino Acid Sequence | Gln24-Leu150 |
| Expression System | E.coli |
| Molecular Weight | 16kDa |
| Purity | >95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | No Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference | 1. Immunity. 1997 Aug;7(2):291-301. |
Background
A novel CC chemokine was identified in the thymus of mouse and human and was designated TECK (thymus-expressed chemokine). TECK has weak homology to other CC chemokines and maps to mouse chromosome 8. Besides the thymus, mRNA encoding TECK was detected at substantial levels in the small intestine and at low levels in the liver. TECK has been reported to chemoattract dendritic cells, thymocytes, and activated macrophages. TECK is a specific agonist for a human orphan receptor called GPR-9-6. Human TECK also induced the in vitro migration of HEK 293/human GPR-9-6 cells. These results confirm that GPR-9-6 is a specific receptor for TECK. Recombinant human TECK is a protein containing 127 amino acid residues, including the four conserved cysteine residues present in CC chemokines.
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