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Description
CD8 alpha&beta Heterodimer His Tag Protein, HumanProduct Specification Species Human Synonyms CD8A&CD8B; CD8 alpha&beta Accession P01732 1P10966 1 Amino Acid Sequence Ser22 Asp182&Leu22 Pro170, with 6His tag at the C terminus Expression System HEK293 Molecular Weight 30 40 kDa, reducing conditions Purity 95% by SDS PAGE Endotoxin <1EU g Conjugation Unconjugated Tag His Tag Physical Appearance Lyophilized Powder Storage Buffer PBS, 5% Trehalose, pH7. 4. Reconstitution Always centrifuge tubes before
Product Specification
| Species | Human |
| Synonyms | CD8A&CD8B; CD8 alpha&beta |
| Accession | P01732-1、P10966-1 |
| Amino Acid Sequence |
Ser22-Asp182&Leu22-Pro170, with 6His tag at the C-terminus
|
| Expression System | HEK293 |
| Molecular Weight |
30-40 kDa, reducing conditions
|
| Purity | ＞95% by SDS-PAGE |
| Endotoxin | <1EU/μg |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer |
PBS, 5% Trehalose, pH7.4.
|
| Reconstitution |
|
| Stability & Storage |
Lyophilized protein should be stored at ≤ -20°C, stable for one year after receipt. |
Background
CD8 is a heterodimeric membrane glycoprotein on MHC class I-restricted T lymphocytes that cooperates with the alpha beta CD3 TCR in the recognition of MHC class I molecules presenting antigenic peptides. Cell surface CD8 molecules exist as either alpha/alpha homodimers or alpha/beta heterodimers, and most CD8+ T cells that undergo differentiation in the thymus express alpha/beta heterodimers. The CD8 b chain appears to be important for the thymic maturation of CD8+ T cells, because the number of mature CD8 single-positive T cells is decreased in CD8b gene-disrupted mice and most CD8+ T cells among gut intraepithelial lymphocytes in thymectomized mice express CD8 alpha/alpha homodimers.
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