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Description
TLR7 Recombinant Rabbit mAb (S-2123-15)Product Specification Host Rabbit Antigen TLR7 Synonyms Toll like receptor 7 Immunogen Synthetic Peptide Location Lysosome, Endosome, Endoplasmic reticulum membrane Accession Q9NYK1 Clone Number S 2123 15 Antibody Type Recombinant mAb Isotype IgG Application WB Reactivity Hu Positive Sample Ramos, Daudi Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS, 40% Glycerol, 0. 05% BSA, 0.
Product Specification
| Host | Rabbit |
| Antigen | TLR7 |
| Synonyms | Toll-like receptor 7 |
| Immunogen | Synthetic Peptide |
| Location | Lysosome, Endosome, Endoplasmic reticulum membrane |
| Accession | Q9NYK1 |
| Clone Number | S-2123-15 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB |
| Reactivity | Hu |
| Positive Sample | Ramos, Daudi |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu |
Background
TLR7, or Toll-like receptor 7, is a protein that plays a crucial role in the innate immune system. It is a member of the Toll-like receptor family, which are pattern recognition receptors that detect pathogen-associated molecular patterns (PAMPs). TLR7 is primarily expressed in immune cells such as plasmacytoid dendritic cells and macrophages, and it specifically recognizes single-stranded RNA from viruses, helping to initiate an immune response against viral infections. Activation of TLR7 leads to the production of type I interferons and pro-inflammatory cytokines, which are vital for antiviral defense. Additionally, TLR7 has been implicated in autoimmune diseases due to its potential to recognize self-RNAs under certain conditions, and it is also a target for research in the development of antiviral therapies and immune modulators.
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