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Description
Phospho-PERK (Thr980) Recombinant Rabbit mAb (S-1801-106)Product Specification Host Rabbit Antigen Phospho PERK (Thr980) Synonyms Eukaryotic translation initiation factor 2 alpha kinase 3; PRKR like endoplasmic reticulum kinase; Pancreatic eIF2 alpha kinase; Protein tyrosine kinase EIF2AK3; Pek; Perk; Eif2ak3 Immunogen Synthetic Peptide Location Endoplasmic reticulum Accession Q9Z2B5 Clone Number S 1801 106 Antibody Type Recombinant mAb Isotype IgG Application WB Reactivity Hu Positive Sample HeLa treated
Product Specification
| Host | Rabbit |
| Antigen | Phospho-PERK (Thr980) |
| Synonyms | Eukaryotic translation initiation factor 2-alpha kinase 3; PRKR-like endoplasmic reticulum kinase; Pancreatic eIF2-alpha kinase; Protein tyrosine kinase EIF2AK3; Pek; Perk; Eif2ak3 |
| Immunogen | Synthetic Peptide |
| Location | Endoplasmic reticulum |
| Accession | Q9Z2B5 |
| Clone Number | S-1801-106 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB |
| Reactivity | Hu |
| Positive Sample | HeLa treated with 1 µM thapsigargin |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| Dot Blot | 1:1000 | |
| WB | 1:1000 | Hu |
Background
Phospho-PERK (Thr980) is a phosphorylated form of the protein kinase-like endoplasmic reticulum kinase (PERK), a type I transmembrane protein located in the endoplasmic reticulum (ER). It plays a crucial role in the unfolded protein response (UPR) by activating itself through oligomerization and autophosphorylation at threonine 980 (Thr980) in response to ER stress and the accumulation of misfolded proteins. This phosphorylation enhances PERK's activity, allowing it to phosphorylate eukaryotic translation initiation factor 2 alpha (eIF2α), which leads to the attenuation of translation initiation and global protein synthesis. This process helps protect cells from the toxic effects of misfolded proteins and maintains cellular homeostasis. Additionally, the activation of PERK is associated with cell cycle arrest due to the loss of cyclin D1 and the regulation of genes involved in metabolism, redox status, and apoptosis.
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