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Description
Alexa Fluor® 647 Mouse Anti-Human HLA-DR Antibody (S-R566)Product Specification Host Mouse Antigen HLA DR Synonyms HLA class II histocompatibility antigen, DR alpha chain; MHC class II antigen DRA; HLA DRA1; HLA DRA Location Lysosome, Endosome, Cell membrane, Endoplasmic reticulum Accession P01903 Clone Number S R566 Antibody Type Mouse mAb Isotype IgG2a Application FCM Reactivity Hu Positive Sample Human PBMC Purification Protein A Concentration 0. 2 mg ml Conjugation Alexa Fluor 647 Physical Appearance
Product Specification
| Host | Mouse |
| Antigen | HLA-DR |
| Synonyms | HLA class II histocompatibility antigen, DR alpha chain; MHC class II antigen DRA; HLA-DRA1; HLA-DRA |
| Location | Lysosome, Endosome, Cell membrane, Endoplasmic reticulum |
| Accession | P01903 |
| Clone Number | S-R566 |
| Antibody Type | Mouse mAb |
| Isotype | IgG2a |
| Application | FCM |
| Reactivity | Hu |
| Positive Sample | Human PBMC |
| Purification | Protein A |
| Concentration | 0.2 mg/ml |
| Conjugation | Alexa Fluor® 647 |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 1% BSA, 0.3% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Dilution
| application | dilution | species |
| FCM | 5μl per million cells in 100μl volume | Hu |
Background
HLA-DR is a subtype of the human leukocyte antigen (HLA) complex, specifically classified as a class II molecule, and is encoded by genes located on chromosome 6. It plays a crucial role in the immune system by presenting peptide antigens to CD4+ T cells, which subsequently trigger adaptive immune responses, including the activation of B cells and the production of antibodies. HLA-DR is primarily expressed on antigen-presenting cells such as macrophages, dendritic cells, and B cells, and its expression levels can indicate the degree of immune system activation. This molecule is also significant in clinical settings, as it is associated with various autoimmune diseases (e.g., rheumatoid arthritis linked to HLA-DR4) and is a key factor in determining the success of organ transplants. Additionally, HLA-DR has been studied in the context of cancer immunotherapy, where its expression on tumor cells can influence the effectiveness of immune-mediated tumor suppression.
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Exchange/Return Notes
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