SKU: 68609897295

MAPKAPK-2 Recombinant Rabbit mAb (S-2641-58)

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Description

MAPKAPK-2 Recombinant Rabbit mAb (S-2641-58)Product Specification Host Rabbit Antigen MAPKAPK 2 Synonyms MAP kinase activated protein kinase 2; MAPK activated protein kinase 2; MAPKAP kinase 2; MAPKAP K2; MK 2; MK2; MAPKAPK2 Immunogen Synthetic Peptide Location Cytoplasm, Nucleus Accession P49137 Clone Number S 2641 58 Antibody Type Recombinant mAb Isotype IgG Application WB Reactivity Hu, Ms, Rt, Mk Positive Sample HeLa treated with UV (100 mJ cm2, 1 hour recovery), 293T, A431, NIH 3T3, MEF,

Product Specification


Host Rabbit
Antigen MAPKAPK-2
Synonyms MAP kinase-activated protein kinase 2; MAPK-activated protein kinase 2; MAPKAP kinase 2; MAPKAP-K2; MK-2; MK2; MAPKAPK2
Immunogen Synthetic Peptide
Location Cytoplasm, Nucleus
Accession P49137
Clone Number S-2641-58
Antibody Type Recombinant mAb
Isotype IgG
Application WB
Reactivity Hu, Ms, Rt, Mk
Positive Sample HeLa treated with UV (100 mJ/cm2, 1 hour recovery), 293T, A431, NIH/3T3, MEF, mouse brain, mouse spleen, C6, rat brain, rat spleen, COS-7
Predicted Reactivity Hm, Rb
Purification Protein A
Concentration 0.5 mg/ml
Conjugation Unconjugated
Physical Appearance Liquid
Storage Buffer

PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300

Stability & Storage

12 months from date of receipt / reconstitution, -20 °C as supplied

Dilution


application dilution species
WB 1:1000-1:2000 Hu, Ms, Rt, Mk

Background

MAPKAPK-2 (commonly referred to as MK2) is a serine/threonine protein kinase encoded by the MAPKAPK2 gene and serves as the most pivotal direct substrate of p38 MAPK, acting as a signaling hub in inflammation, tumorigenesis, the DNA damage response, and cellular senescence. In its resting state, MK2 remains inactive due to an autoinhibitory conformation formed between its C-terminal regulatory domain and its kinase domain. Upon exposure to cellular stress, inflammatory cytokines, or pathogen stimulation, p38α phosphorylates MK2 at Thr334, triggering a conformational switch that simultaneously exposes a nuclear export signal (NES) —promoting p38-bound MK2 translocation to the cytoplasm—and masks its C-terminal nuclear localization signal (NLS) , thereby directing p38 signaling precisely toward cytoplasmic targets. Activated MK2 executes pleiotropic functions via phosphorylation of a diverse substrate repertoire: in the cytoplasm, it phosphorylates HSP27 to remodel the actin cytoskeleton and facilitate cell migration; in RNA metabolism, it phosphorylates ARE-binding proteins such as Tristetraprolin (TTP) and hnRNP A0, causing their 14-3-3-mediated sequestration and inactivation, thereby stabilizing the mRNAs of pro-inflammatory cytokines including TNF-α, IL-6, and IL-1β—a core mechanism driving chronic inflammation. Within the nucleus, MK2 phosphorylates transcription factors such as CREB and SRF, and contributes to maintaining the G2/M checkpoint by regulating the stability of GADD45A mRNA following DNA damage. Recent studies have expanded the functional landscape of MK2 far beyond the classical inflammatory axis: within the tumor microenvironment, MK2 promotes cell survival, drives epithelial-mesenchymal transition (EMT), and confers chemoresistance (e.g., desensitizing pancreatic cancer to gemcitabine and tongue squamous cell carcinoma to paclitaxel), positioning it as a promising target for overcoming drug resistance. In senescent cells, the mTOR pathway selectively upregulates MK2 translation via 4EBP1; the accumulated MK2 then phosphorylates ZFP36L1, relieving its degradation of SASP component mRNAs and thereby establishing the senescence-associated secretory phenotype (SASP).

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SKU: 68609897295

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4.6 ★★★★★
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Jewell Urbano
Houston, US
★★★★★ 5
Wow.
Format: Kindle
Okay I’m usually not one for stand-alone’s I’m an avid series reader but my goodness am I so happy I read this! This story was brilliant & so absolutely mesmerizing. I loved reading about each character and their struggles as well as what helped them to move forward. The ending definitely brought tears to my eyes so hard. I truly wasn’t expecting some of what happened in this story. There is about to be a spoiler I am going to reveal so please stop reading if you don’t want the spoiler !!!! ⚠️ ⛔️ ‼️ I loved that the author didn’t do what most authors do with irredeemable male characters. I truly was hoping that Nate Jr. would be apart of the pack after the way he treated Astrea bc he truly didn’t deserve it. Though I must say you did a wonderful job or redeeming him as a person. I cried my eyes out when he walked into the story. I was truly terrified he was going to be a bad guy to the end. However you truly did him such a justice by having him realize his faults & having him redeem himself in the most wonderful way. I’m so sad that he didn’t get to hear how much his brother loved him & forgave him before dying. But again you wrote that ending so beautifully & I just can’t express how much I loved this story & how you took a different route than most authors I have read have. You are a remarkable author Cinder Blaze & I thank you generously for creating such a masterpiece.
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Reviewed in the United States on April 28, 2025
K
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Kristen Linscott
Carnegie, US
★★★★★ 4
Omegaverse
Format: Kindle
I was pleasantly surprised by this omega verse book. This 1 definitely had a few new twists And I really enjoyed reading it. The main female character was a badass and awesome. She had 1 best friend I wish we could have seen a little bit more of their friendship in this book. Her relationship with the male characters was good not to contrived or super instantaneous. And we had some fun plot twists that I didn't expect. I wish we had more of a follow up on the situation with her family her background and her mother who was a wench. I would definitely recommend this book.
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Reviewed in the United States on April 9, 2025
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Amanda
Boise, US
★★★★★ 5
Wow. Just wow. An amazing read
Format: Kindle
This book was eloquently written, or should I say the authors writing style is very eloquent? I loved the characters, and the story was quite compelling. I absolutely loved the FMC, she's a BA who doesn't take any crap & gives as good as she gets. A certain person certainly got his just desserts & then some, the earlier scenes of which were quite satisfying, had me punching the air & everything haha. All in all 20/10, great read
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Reviewed in the United States on November 29, 2024
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Lauren
Port Orchard, US
★★★★★ 3
My opinion
Format: Kindle
Let me preface this by saying I really liked the story and the characters however, this book is in desperate need of some sort of editing. It's not misspelled words or formatting, but continuous run on sentences. Redundancies within the sentences. There were a couple of paragraphs that I had to go back and reread 3 or 4 times. Overall, I'd say it was worth the read.
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Reviewed in the United States on May 29, 2025
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Amazon Customer
Alexandria, US
★★★★★ 5
Beautiful
Format: Kindle
I love omegaverses I had looked at this one multiple times thinking it's just another book about cocky rock star guys that let fame get to their heads and there are parts like that so I wasn't 100% off. I started reading the second book and met the fmc Astraea from the first one,after she had a run in with the aphla from the gym.😁 it gave me the push to stop and read book one first and im so glad I did this book was amazing their was so many characters I fell in love with hoping they will find their happily ever after. the guys were great, the plot was 🎯, and the ending had me 😭😭😭. I was wondering how nate could ever redeem himself, and he did. the last scene with him was sad, but I also felt it was beautiful. thank you to the author for making a beautiful omegaverse book that gave me all the feels. now I'm jumping straight into book two.
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Reviewed in the United States on March 25, 2025

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