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Description
DUSP6 His Tag Protein, HumanProduct Specification Species Human Synonyms Dual specificity protein phosphatase 6, Dual specificity protein phosphatase PYST1, Mitogen activated protein kinase phosphatase 3 (MAP kinase phosphatase 3; MKP 3) Accession Q16828 Amino Acid Sequence Met1 Thr381, with N terminal His Expression System E. coli Molecular Weight 43kDa Purity 95% by SDS PAGE Endotoxin <0. 1EU g Conjugation Unconjugated Tag His Tag Physical Appearance Lyophilized Powder Storage
Product Specification
| Species | Human |
| Synonyms | Dual specificity protein phosphatase 6, Dual specificity protein phosphatase PYST1, Mitogen-activated protein kinase phosphatase 3 (MAP kinase phosphatase 3; MKP-3) |
| Accession | Q16828 |
| Amino Acid Sequence | Met1-Thr381, with N-terminal His |
| Expression System | E.coli |
| Molecular Weight | 43kDa |
| Purity | ＞95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, 2mM TCEP, pH7.4 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference | Nat Commun. 2022 Nov 5;13(1):6672. |
Background
Dual-specific phosphatase-6 (DUSP6), also known as mitogen-activated protein kinase phosphatase-3 (MKP3), has been characterized as a negative feedback regulator of ERK1/2 signaling. It serves a specific and conserved function on the dephosphorylation of extracellular signal-regulated kinase 1/2 (ERK1/2). DUSP6 is a cytoplasmic DUSP known to catalyze the removal of phosphate groups from threonine and tyrosine residues on Erk1/2, Which belongs to a family of 25 protein phosphatases that dephosphorylate phosphotyrosine and phosphoserine/phosphothreonine residues within the same substrate.
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