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Description
SOCS3 Recombinant Rabbit mAb (S-2238-34)Product Specification Host Rabbit Antigen SOCS3 Synonyms Suppressor of cytokine signaling 3; SOCS 3; Cytokine inducible SH2 protein 3 (CIS 3); STAT induced STAT inhibitor 3 (SSI 3); CIS3; SSI3 Immunogen Recombinant Protein Location Cytoplasm Accession O14543 Clone Number S 2238 34 Antibody Type Recombinant mAb Isotype IgG Application WB Reactivity Hu, Ms Positive Sample HeLa, Ramos, Jurkat, RAW264. 7 Purification Protein A Concentration 0. 5 mg ml
Product Specification
| Host | Rabbit |
| Antigen | SOCS3 |
| Synonyms | Suppressor of cytokine signaling 3; SOCS-3; Cytokine-inducible SH2 protein 3 (CIS-3); STAT-induced STAT inhibitor 3 (SSI-3); CIS3; SSI3 |
| Immunogen | Recombinant Protein |
| Location | Cytoplasm |
| Accession | O14543 |
| Clone Number | S-2238-34 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB |
| Reactivity | Hu, Ms |
| Positive Sample | HeLa, Ramos, Jurkat, RAW264.7 |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu, Ms |
Background
SOCS3 (Suppressor of Cytokine Signaling 3) is a critical regulator of cytokine signaling pathways. It is an intracellular protein that plays a key role in modulating immune responses and maintaining homeostasis. SOCS3 primarily functions by inhibiting the JAK-STAT signaling pathway, a crucial pathway activated by various cytokines such as interleukins and interferons. By binding to activated JAKs (Janus kinases) and preventing their phosphorylation of downstream targets like STAT proteins, SOCS3 effectively dampens the signaling cascade, thereby controlling the intensity and duration of cytokine-mediated effects. Its expression is often induced by cytokines themselves, creating a negative feedback loop that helps prevent excessive immune activation. Dysregulation of SOCS3 has been implicated in several diseases, including chronic inflammation and autoimmune disorders, highlighting its importance in maintaining proper immune function and overall health.
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