SKU: 65185124881

FITC Mouse Anti-Human CD146 Antibody (S-3679)

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Description

FITC Mouse Anti-Human CD146 Antibody (S-3679)Product Specification Host Mouse Antigen CD146 Synonyms Cell surface glycoprotein MUC18; Cell surface glycoprotein P1H12; Melanoma cell adhesion molecule; Melanoma associated antigen A32; Melanoma associated antigen MUC18; S endo 1 endothelial associated antigen; MUC18; MCAM Location Membrane Accession P43121 Clone Number S 3679 Antibody Type Mouse mAb Isotype IgG1,k Application FCM Reactivity Hu Positive Sample HeLa Purification Protein G

Product Specification


Host Mouse
Antigen CD146
Synonyms Cell surface glycoprotein MUC18; Cell surface glycoprotein P1H12; Melanoma cell adhesion molecule; Melanoma-associated antigen A32; Melanoma-associated antigen MUC18; S-endo 1 endothelial-associated antigen; MUC18; MCAM
Location Membrane
Accession P43121
Clone Number S-3679
Antibody Type Mouse mAb
Isotype IgG1,k
Application FCM
Reactivity Hu
Positive Sample HeLa
Purification Protein G
Concentration 0.2 mg/ml
Conjugation FITC
Physical Appearance Liquid
Storage Buffer

PBS, 1% BSA, 0.3% Proclin 300

Stability & Storage

12 months from date of receipt / reconstitution, 2 to 8 °C as supplied

Dilution


application dilution species
FCM 5μl per million cells in 100μl volume Hu

Background

CD146, also known as melanoma cell adhesion molecule (MCAM), is a 113-kDa, heavily glycosylated type-I transmembrane glycoprotein of the immunoglobulin superfamily that consists of five Ig-like domains (V-V-C2-C2-C2), a single transmembrane segment and a cytoplasmic tail existing in a long and a short splice isoform; initially identified on melanoma cells, it now is recognized as a multifunctional adhesion and signaling receptor widely expressed on endothelial cells, pericytes, smooth muscle, activated T cells and various stem cells that, through homophilic interactions and ligands such as laminin-411, Wnt5a and galectin-1, orchestrates angiogenesis, vascular integrity, cell migration, immune-cell trafficking and epithelial–mesenchymal transition, while its overexpression and elevated glycosylation in melanoma, renal, prostate, lung, pancreatic and other cancers correlate with tumor progression, metastasis and poor prognosis, and its soluble ectodomain (sCD146) released by metalloprotease shedding functions as a circulating biomarker, making CD146 a valuable diagnostic and therapeutic target in oncology and inflammatory diseases.

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SKU: 65185124881

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4.7 ★★★★★
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Efren
Charlottesville, US
★★★★★ 5
Small size, but holds up to two sponges
Needed something to hold my sponges in the sink and this did the job
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on May 13, 2026
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"laurasinda"
Natrona Heights, US
★★★★★ 3
need a smooth sink surface for this to work
Color: Silver
Suction cups didn't stick to my sink and kept falling; to be fair, surface of my sink is textured.
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Reviewed in the United States on June 12, 2025
M
Verified Purchase
Mister E.
Louisville, US
★★★★★ 5
Three months later, it's a keeper
Color: Silver
I hate it when reviews are left one day after the product arrives. At that point, there's no way of knowing if the item is going to last. When my last sink caddy went bad (the suction cups rotted out and the wires had started to rust), I ordered this as a replacement. Inexpensive, functional, worth a try. There were two things that impressed me when this arrived. The suction cups weren't permanently mounted, so if they fell apart, the caddy was still worthwhile. Secondly, the company offered free replacement suction cups if the time came I needed them. That struck me as above-and-beyond; I had no idea this was part of the package. I'm happy with this. It looks good, I detach the sink caddy regularly when I want to move it out of the way, and it pops right back into place. For the money, I don't think you can beat it.
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Reviewed in the United States on March 7, 2021
M
Verified Purchase
Michelle bullard
Battle Creek, US
★★★★★ 5
Stable and easy to assemble
I used these to support a heavy piece of countertop would to create a side table. Looks great and holds steady.
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Reviewed in the United States on February 15, 2023
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Charles Clerici
Alexandria, US
★★★★★ 5
Great
All pieces cut to perfection, went together perfectly
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Reviewed in the United States on October 22, 2023

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