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Description
CD21 Mouse mAb (S-764-18)Product Specification Host Mouse Antigen CD21 Synonyms Complement receptor type 2, Cr2, Complement C3d receptor, Epstein Barr virus receptor (EBV receptor) Immunogen Recombinant Protein Location Cell membrane Accession P20023 Clone Number S 764 18 Antibody Type Mouse mAb Isotype IgG1,k Application ICC, FCM Reactivity Hu Purification Protein G Concentration 2 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS, 40% Glycerol, 0.
Product Specification
| Host | Mouse |
| Antigen | CD21 |
| Synonyms | Complement receptor type 2, Cr2, Complement C3d receptor, Epstein-Barr virus receptor (EBV receptor) |
| Immunogen | Recombinant Protein |
| Location | Cell membrane |
| Accession | P20023 |
| Clone Number | S-764-18 |
| Antibody Type | Mouse mAb |
| Isotype | IgG1,k |
| Application | ICC, FCM |
| Reactivity | Hu |
| Purification | Protein G |
| Concentration | 2 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05%BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| FCM | 1:200 | null |
| ICC | 1:500 | null |
Background
CD21 is involved in the complement system. It binds to iC3b (inactive derivative of C3b), C3dg, or C3d.B cells express CD21 receptors on their surfaces, allowing the complement system to play a role in B-cell activation and maturation. CD21 interacts with CD19 and on mature B cells forms a complex with CD81 (TAPA-1). The CD21-CD19-CD81 complex is often called the B cell co-receptor complex, because CD21 binds to opsonized antigens through attached C3d (or iC3b or C3dg) when the B-cell receptor binds antigen. This results in the B cell having greatly enhanced response to the antigen. Epstein-Barr virus (EBV) can bind CD21, enabling EBV to enter and infect B cells.
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