SKU: 6469880279

PE Mouse Anti-human HLA-ABC Antibody (S-R526)

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Description

PE Mouse Anti-human HLA-ABC Antibody (S-R526)Product Specification Host Mouse Antigen HLA ABC Synonyms HLA class I histocompatibility antigen; A alpha chain; Human leukocyte antigen A (HLA A); HLA class I histocompatibility antigen; B alpha chain; Human leukocyte antigen B (HLA B); HLA class I histocompatibility antigen, C alpha chain; HLA Cw; Human leukocyte antigen C Location Cell membrane Accession P04439P01889P10321 Clone Number S R526 Antibody Type Mouse mAb Isotype IgG2a,k Application FCM

Product Specification


Host Mouse
Antigen HLA-ABC
Synonyms HLA class I histocompatibility antigen; A alpha chain; Human leukocyte antigen A (HLA-A); HLA class I histocompatibility antigen; B alpha chain; Human leukocyte antigen B (HLA-B); HLA class I histocompatibility antigen, C alpha chain; HLA-Cw; Human leukocyte antigen C
Location Cell membrane
Accession P04439、P01889、P10321
Clone Number S-R526
Antibody Type Mouse mAb
Isotype IgG2a,k
Application FCM
Reactivity Hu
Positive Sample human peripheral blood Leukocytes
Purification Protein A
Concentration 0.2 mg/ml
Conjugation PE
Physical Appearance Liquid
Storage Buffer

PBS, 1% BSA, 0.3% Proclin 300

Stability & Storage

12 months from date of receipt / reconstitution, 2 to 8 °C as supplied

Dilution


application dilution species
FCM 1.25μl per million cells in 100μl volume Hu

Background

HLA-ABC (also termed HLA class I classical heavy chains A, B, and C) are 44 kDa type I transmembrane glycoproteins encoded within the major histocompatibility complex on chromosome 6p21.3; each non-covalently associates with the invariant light chain β2-microglobulin (12 kDa) to form a peptide-binding heterodimer that is constitutively expressed on nearly all nucleated cells. These molecules serve as the principal conduit for presenting endogenously derived 8–11-mer peptides to CD8⁺ cytotoxic T lymphocytes, thereby orchestrating immune surveillance against intracellular pathogens, tumors, and transplanted tissues. Polymorphic residues concentrated in the α1 and α2 domains create an extraordinary diversity (thousands of alleles catalogued in the IPD-IMGT/HLA database), which underpins population-level resistance to infection yet constitutes the primary barrier to solid-organ and hematopoietic stem-cell transplantation through allorecognition. Beyond antigen presentation, HLA-ABC interacts with NK-cell inhibitory receptors (KIR and LILRB1) to calibrate natural killer cell responses, and its surface levels are dynamically modulated by cytokines such as interferon-γ, viral immune evasion proteins (e.g., HIV Nef, CMV US2/US11), and oncogenic signaling pathways, making quantitative HLA-ABC expression a prognostic biomarker in cancer immunotherapy.

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SKU: 6469880279

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4.9 ★★★★★
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Verified Purchase
Ron Sieloff
Port Orchard, US
★★★★★ 5
Quality product
Color: Green & Yellow & Blue
Durable. Tested negative for lead.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on April 14, 2026
K
K. Mair
Massapequa, US
★★★★★ 3
Fun but easy to destroy
Color: Green & Yellow & Blue
We foster puppies and go through a ton of toys. These soft, latex toys are great for non-super chewers, whether puppies or small to medium dogs. Our 20-week-old foster puppy has had a great time with hers, which still squeaks. She is fairly gentle and enjoys squeaking her toys, but is not destructive. If you have super chewers, these will not last for even a minute. One of our dogs got a hold of one toy after a few days and demolished it in literally 6 seconds. The price is quite high for toys if in this style, as you get three of them for $16, and typically you can get similar toys for a much lower price, but they do have a great squeak and the long necks have really pleased the puppy. I think that for the right dog, these would be great, and I would recommend them, but avoid them if your dog likes to destroy their toys because they are terribly easy to rip apart.
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Reviewed in the United States on December 7, 2025
L
Verified Purchase
Linda Ramos
Omaha, US
★★★★★ 5
Fun new toys
Color: Yellow & Grey & Brown
My dog loves him. They’re easy to squeak and carry in his mouth so it’s a bonus bonus for him. He’s a puppy so he’s not the most coordinated thing yet.
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Reviewed in the United States on December 30, 2025
S
Verified Purchase
Shelly N.
Grantham, US
★★★★★ 2
Not for dogs who chew
Color: Green & Yellow & Blue
My dog loved them, but they were destroyed in 2 days.
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Reviewed in the United States on January 31, 2026
N
Verified Purchase
N Epp
Lexington, US
★★★★★ 5
A new favorite toy
Color: Yellow & Grey & Brown
My dog loves these!
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Reviewed in the United States on January 5, 2026

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