SKU: 6360789387

FITC Human Anti-Human GM-CSF Antibody (S-2816)

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Description

FITC Human Anti-Human GM-CSF Antibody (S-2816)Product Specification Host Human Antigen GM CSF Synonyms Granulocyte macrophage colony stimulating factor; Colony stimulating factor (CSF); Molgramostin; Sargramostim; GMCSF; CSF2 Location Secreted Accession P04141 Clone Number S 2816 Antibody Type Recombinant mAb Application ICFCM Reactivity Hu Positive Sample Th1 Polarization Human PBMC Purification Protein A Concentration 0. 2 mg ml Conjugation FITC Physical Appearance Liquid Storage Buffer PBS, 1%

Product Specification


Host Human
Antigen GM-CSF
Synonyms Granulocyte-macrophage colony-stimulating factor; Colony-stimulating factor (CSF); Molgramostin; Sargramostim; GMCSF; CSF2
Location Secreted
Accession P04141
Clone Number S-2816
Antibody Type Recombinant mAb
Application ICFCM
Reactivity Hu
Positive Sample Th1 Polarization Human PBMC
Purification Protein A
Concentration 0.2 mg/ml
Conjugation FITC
Physical Appearance Liquid
Storage Buffer

PBS, 1% BSA, 0.3% Proclin 300

Stability & Storage

12 months from date of receipt / reconstitution, 2 to 8 °C as supplied

Dilution


application dilution species
ICFCM 5μl per million cells in 100μl volume Hu

Background

Granulocyte-macrophage colony-stimulating factor (GM-CSF), also known as CSF2, is a multifunctional glycoprotein cytokine that serves as a critical regulator of hematopoiesis and immune responses by binding to a specific heterodimeric receptor complex composed of an alpha chain (CD116) and a shared beta chain (CD131) on target cells. Primarily produced by activated macrophages, T cells, mast cells, endothelial cells, and fibroblasts in response to inflammatory stimuli, GM-CSF stimulates the proliferation, differentiation, survival, and functional activation of myeloid progenitor cells, driving their development into mature granulocytes (such as neutrophils, eosinophils, and basophils) and monocytes/macrophages while simultaneously enhancing the antimicrobial and antigen-presenting capabilities of these mature cells through mechanisms like increased phagocytosis, oxidative burst, and upregulation of MHC class II molecules. Beyond its physiological role in boosting host defense against infections and maintaining tissue homeostasis, GM-CSF plays a significant pathological role in chronic inflammatory and autoimmune diseases, such as rheumatoid arthritis and multiple sclerosis, where its overproduction contributes to sustained inflammation and tissue damage, making it a prominent therapeutic target for monoclonal antibodies aimed at blocking its signaling pathway, while recombinant forms of the protein (e.g., sargramostim) are clinically utilized to accelerate myeloid recovery following chemotherapy or bone marrow transplantation.

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SKU: 6360789387

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4.8 ★★★★★
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J
Verified Purchase
joe burke
Chelsea, US
★★★★★ 1
Poor quality. Very disappointing
Format: Hardcover, Format: Hardcover
The product said in good shape. This is not good shape. Product is damaged and held together by tape
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on December 11, 2022
L
LoneWolf18
Natrona Heights, US
★★★★★ 4
Pretty funny
Format: Hardcover
The book gives us a more focused outlook on Chieg Wiggum. Full of its funny moments, I`d recomend this to huge Simpsons fans as it seems the shows writers managed to give us another hit.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on January 13, 2014
I
Verified Purchase
I.T.
Birmingham, US
★★★★★ 3
Not the best, but not the worst either
Format: Hardcover
By any means not the funniest book in the series, only the one on Krusty the Clown was more un-funny; but still a worthy addition to your collection and, just like all the others from the series providing a retrospective of anecdotes you might have forgotten.
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Reviewed in the United States on July 22, 2012
P
Verified Purchase
Pen Name
New York, US
★★★★★ 1
One Star
Format: Hardcover
The book I received had 3 pages cut out of it.
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Reviewed in the United States on August 17, 2014
G
Ghost Mutt
Grantham, US
★★★★★ 2
Not that great
Huge "The Simpsons" fan. I watched all the episodes and read a lot of the comics and enjoy most. This one however was quite boring. Turns out I'm just not a big fan of Chief Wiggum. I really enjoyed The "Homer" and "Bart" book. But not this one. Maybe if you love Wiggum you'll love it. If you're not too fond of him then I wouldn't buy it.
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Reviewed in the United States on March 28, 2013

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