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Description
Mouse Anti-Human LAT1/CD98 complex Antibody (S-3441)Product Specification Host Mouse Antigen LAT1 CD98 complex Synonyms Large neutral amino acids transporter small subunit 1; 4F2 light chain (4F2 LC; 4F2LC); CD98 light chain; Integral membrane protein E16 (E16); L type amino acid transporter 1 (hLAT1); Solute carrier family 7 member 5; y+ system cationic amino acid transporter; CD98LC; LAT1 s; MPE16; SLC7A5 Location Lysosome, Cell membrane Accession Q01650 Clone Number S 3441 Antibody Type Mouse mAb
Product Specification
| Host | Mouse |
| Antigen | LAT1/CD98 complex |
| Synonyms | Large neutral amino acids transporter small subunit 1; 4F2 light chain (4F2 LC; 4F2LC); CD98 light chain; Integral membrane protein E16 (E16); L-type amino acid transporter 1 (hLAT1); Solute carrier family 7 member 5; y+ system cationic amino acid transporter; CD98LC; LAT1 s; MPE16; SLC7A5 |
| Location | Lysosome, Cell membrane |
| Accession | Q01650 |
| Clone Number | S-3441 |
| Antibody Type | Mouse mAb |
| Isotype | IgG1,k |
| Application | FCM |
| Reactivity | Hu |
| Positive Sample | A549 |
| Purification | Protein G |
| Concentration | 2 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS pH7.4 |
| Stability & Storage | 12 months from date of receipt / reconstitution, 2 to 8 °C as supplied |
Dilution
| application | dilution | species |
| FCM | 1:50 | Hu |
Background
The LAT1/CD98 complex is a heterodimeric, sodium-independent amino acid transporter composed of the catalytic light chain LAT1 (SLC7A5) and the heavy chain CD98 (4F2hc/SLC3A2), which acts as a chaperone to stabilize LAT1 and escort it to the plasma membrane where it exchanges large neutral amino acids such as leucine, phenylalanine and tryptophan to fuel mTORC1 signaling and support growth, particularly in tumors that overexpress the complex.
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