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Description
PTK7/CCK4 His Tag Protein, MouseProduct Specification Species Mouse Synonyms PTK7, CCK4, Colon carcinoma kinase 4, Inactive tyrosine protein kinase 7, Tyrosine protein kinase like 7 Accession Q8BKG3 Amino Acid Sequence Ala23 Thr696, with C terminal 10*His
Product Specification
| Species | Mouse |
| Synonyms | PTK7, CCK4, Colon carcinoma kinase 4, Inactive tyrosine-protein kinase 7, Tyrosine-protein kinase-like 7 |
| Accession | Q8BKG3 |
| Amino Acid Sequence | Ala23-Thr696, with C-terminal 10*His AIVFIKEPSSQDALQGRRALLRCEVEAPDPVHVYWLLNGVPVQDTERRFAQGSSLSFAAVDRLQDSGAFQCVARDNVTGEEVRSTNASFNIKWIEAGPVVLKHPASEAEIQPQTQVTLRCHIDGHPRPTYQWFRDGTPLSDDQSTHTVSSRERNLTLRPASPEHSGLYSCCAHNAFGQACSSQNFTLSVADESFARVVLAPQDVVVARNEEAMFHCQFSAQPPPSLQWVFEDETPITNRSRPPHLRRAVVFANGSLLLTQVRPRNAGVYRCIGQGQRGPPIVLEATLHLAEIEDMLPFEPRVFIAGDEERVTCPAPQGLPTPSVWWEHAGVPLPAHGRVHQKGLELVFVTIAESDTGVYTCHASNLAGQRRQDVNITVATVPTWLRKPQDSQLEEGKPGYLHCLTQATPKPTVIWYRNQMLISEDSRFEVSKNGTLRINSVEVYDGTLYRCVSSTPAGSIEAQARVQVLEKLKFTPPPQPQQCMEFDKEATVPCSATGREKPTVKWVRADGSSLPEWVTDNAGTLHFARVTRDDAGNYTCIASNEPQGQIRAHVQLTVAVFITFKVEPERTTVYQGHTALLRCEAQGDPKPLIQWKGKDRILDPTKLGPRMHIFQNGSLVIHDVAPEDSGSYTCIAGNSCNIRHTEAPLLVVDKPVMEDSEGPGSPPPYKMIQTGGGSGGGSHHHHHHHHHH |
| Expression System | HEK293 |
| Molecular Weight | 95-110kDa |
| Purity | >95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | His Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference |
1、Lichtig H. et al. (2019) Ptk7 proteolytic fragment proteins function during early xenopus development. Dev Biol. 453(1): 48-55. 2、Damelin M. et al. (2017) A ptk7-targeted antibody-drug conjugate reduces tumor-initiating cells and induces sustained tumor regressions. Sci Transl Med 9 (372): eaag2611. |
Background
Protein tyrosine kinase 7 (PTK7), also known as colon carcinoma kinase 4 (CCK4), is a member of the receptor tyrosine kinase superfamily. PTK7 is a type I transmembrane receptor with a large extracellular domain (ECD) containing 7 Ig-like C2 type loops, a transmembrane domain, and a cytoplasmic tyrosine kinase homology domain. PTK7 has been shown to be an important regulator of the Wnt signaling pathways, both canonical and non-canonical, and is linked to the regulation of the planar cell polarity pathway. Functions in cell adhesion, cell migration, cell polarity, proliferation, actin cytoskeleton reorganization and apoptosis. Has a role in embryogenesis, epithelial tissue organization and angiogenesis.
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4.9 ★★★★★
Based on 14 reviews
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Product Reviews
★★★★★ 5
Great Ball
Size: 6 Inch, Color: Red
Our Little Goldendoodle Loves this ball & I like that it has so many straps to grab so I'm not getting the slimy part. It does not come already inflated so make sure you or a neighbor have an air compressor to blow it up because even though it came with a little pump I can't imagine how many weeks I'd have been pumping that without noticing any difference.
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Reviewed in the United States on May 2, 2026
★★★★★ 5
Virtually indestructible
Size: 8 Inch, Color: Red
Long lasting ball for a large dog. Bought the first one a few years ago. Its been outside all this time, still full of air and was virtually impossible for my large dog to destroy it. The weather affected the surface so ordered a new one. This has outlasted all the other balls.
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Reviewed in the United States on April 14, 2026
★★★★★ 4
Great toy for larger dogs
Size: 8 Inch, Color: Pink
This is holding up pretty well with my Great Pyrenees pup. She was able to pull all of the tags off-but the ball is intact for several weeks!
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Reviewed in the United States on June 24, 2025
★★★★★ 5
QDAN has great durable dog toys
Size: 8 Inch, Color: Yellow
It’s very durable ball lots of fun for dogs
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Reviewed in the United States on March 24, 2026
★★★★★ 5
So much fun
Size: 8 Inch, Color: Pink
Best money ever spent hours of fun. We have 3 dogs. They all love to play with this toy. We got the size 3 large is what we ordered. I'm not going to lie I thought it would be bigger when I ordered it. Two of our dogs are large breeds and the other is medium. It's not too big for the medium to play with it. It comes with a ball pump included so convenient. The little tabs are very durable. I can't recommend this enough. This has no squeaking or any sounds. It's nice that you can play with your four legged companion or you can have them play tug or just enjoy pushing the ball around. It is very versatile in play and stimulation.
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Reviewed in the United States on June 8, 2025