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Description
GPHN Recombinant Rabbit mAb (S-3167-63)Product Specification Host Rabbit Antigen GPHN Synonyms Gephyrin; GPH; KIAA1385 Immunogen Synthetic Peptide Location Cytoplasm, Cell membrane, Cell projection Accession Q9NQX3 Clone Number S 3167 63 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P Reactivity Hu, Ms, Rt Positive Sample HEK 293, SH SY5Y, MCF7, U 2 OS, Jurkat, RAW264. 7, mouse testis, mouse brain, mouse heart, PC 12, C6, rat testis, rat brain Purification Protein A
Product Specification
| Host | Rabbit |
| Antigen | GPHN |
| Synonyms | Gephyrin; GPH; KIAA1385 |
| Immunogen | Synthetic Peptide |
| Location | Cytoplasm, Cell membrane, Cell projection |
| Accession | Q9NQX3 |
| Clone Number | S-3167-63 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P |
| Reactivity | Hu, Ms, Rt |
| Positive Sample | HEK-293, SH-SY5Y, MCF7, U-2 OS, Jurkat, RAW264.7, mouse testis, mouse brain, mouse heart, PC-12, C6, rat testis, rat brain |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu, Ms, Rt |
| IHC-P | 1:2000 | Hu, Ms, Rt |
Background
GPHN (gephyrin) is a 93-kDa multifunctional scaffold protein that self-assembles into a hexagonal lattice beneath the postsynaptic membrane of inhibitory synapses, where it simultaneously anchors both glycine and GABA type A receptors to subsynaptic microtubules and actin cytoskeleton, thereby clustering and immobilizing these receptors to ensure reliable inhibitory neurotransmission, while also possessing dual enzymatic activities (molybdopterin adenylyltransferase and molybdotransferase) essential for the biosynthesis of the molybdenum cofactor, and its alternative splicing, extensive post-translational modifications and dynamic exchange at synapses modulate inhibitory synaptic strength and plasticity, with mutations or altered expression of GPHN linked to epilepsy, autism spectrum disorders, schizophrenia and molybdenum cofactor deficiency.
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