SKU: 58128872776

PRAME Recombinant Rabbit mAb (S-1876-173)

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Description

PRAME Recombinant Rabbit mAb (S-1876-173)Product Specification Host Rabbit Antigen PRAME Synonyms Melanoma antigen preferentially expressed in tumors; Opa interacting protein 4 (OIP 4); Preferentially expressed antigen of melanoma; MAPE; OIP4 Immunogen Recombinant Protein Location Cell membrane, Cytoplasm, Nucleus Accession P78395 Clone Number S 1876 173 Antibody Type Recombinant mAb Isotype IgG Application WB, ICC Reactivity Hu Positive Sample A375, U 2 OS, K562, SK MEL 2 Purification

Product Specification


Host Rabbit
Antigen PRAME
Synonyms Melanoma antigen preferentially expressed in tumors; Opa-interacting protein 4 (OIP-4); Preferentially expressed antigen of melanoma; MAPE; OIP4
Immunogen Recombinant Protein
Location Cell membrane, Cytoplasm, Nucleus
Accession P78395
Clone Number S-1876-173
Antibody Type Recombinant mAb
Isotype IgG
Application WB, ICC
Reactivity Hu
Positive Sample A375, U-2 OS, K562, SK-MEL-2
Purification Protein A
Concentration 0.5 mg/ml
Conjugation Unconjugated
Physical Appearance Liquid
Storage Buffer

PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300
Stability & Storage

12 months from date of receipt / reconstitution, -20 °C as supplied

Dilution


application dilution species
WB 1:1000 Hu
ICC 1:500 Hu

Background

PRAME (Preferentially Expressed Antigen of Melanoma) is a protein encoded by the PRAME gene, belonging to the cancer-testis antigen family. It is predominantly expressed in various cancers, including melanoma, breast cancer, lung cancer, and leukemia, but is largely absent in normal tissues except for testis, ovary, placenta, and a few others. PRAME can inhibit retinoic acid signaling, thereby promoting cell proliferation and contributing to tumorigenesis. Due to its restricted expression pattern, PRAME is considered a promising target for cancer immunotherapy, with ongoing research exploring PRAME-specific vaccines and cellular immunotherapies.

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SKU: 58128872776

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4.6 ★★★★★
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B
Verified Purchase
brandon holmes
Carnegie, US
★★★★★ 5
great
Format: Paperback
all the comics are good and cheap
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on August 25, 2014
T
Verified Purchase
Tom Trails
Fort Morgan, US
★★★★★ 1
I love the show, hate this book
Format: Paperback
The Simpsons is one of the funniest TV shows ever. It doesn't translate well to paper at all in this book. This is not funny. It reads like some wannabe comedy writer trying to imitate the Simpsons. The book's credits list Matt Groening as the the "publisher". It lists 7 writers, none of whom is Groening. It also lists a creative director, art director, and multiple "contributing artists", none of whom are Groening. In fact, comparing the list of writers for this book to the list of the show's writers on Wikipedia, none of the show's writers contributed to this book. Maybe that's why it doesn't feel like the show at all. Same characters, lame dialogue, not funny. Too bad.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on December 20, 2008
L
L. Aiello
Waukegan, US
★★★★★ 5
HO HO HO from the Simpsons! Holiday cheer is here!
Format: Paperback
The Simpsons 'Holiday Humdinger' is an excellent collection of comics, and this one in particular hits on many different levels. Not only are we seeing the main characters that we love placed in crazy holiday situations, but a lot of careful attention was poured into clever in-jokes and homage's to past characters and episodes. Since the Simpsons brand comics usually play out like a half hour episode, their comic production values have been excellent. The flow of the story, the perfect colors, the likeness of the characters....all of these elements make the comic strips come together in a great way. In the case of this holiday edition, not only do we get the longer stories but we also get much more: A few two-page spreads of Christmas silliness courtesy of the Springfield Elementary gym, the power plant, and the comic book store. In these bits, there is so much going on at once that is takes a 2nd and 3rd glance to make sure you don't miss all the laughs. We are also treated to holiday "cards," coming from many Springfield hot spots and major players. Fans of the series will think back to some past TV episodes to make the connection with some of these holiday greetings! There are a few Angry Dad cameos as well! And Christmas would certainly feel empty without Itchy & Scratchy, so get ready for a great story involving our favorite cat and mouse. As with many other Simpsons collections, many of these comics may have appeared in the monthly editions in the past. So beware if you do not like the idea of getting repeat material. Otherwise, this is an absolute holiday treat ! Enjoy!
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Reviewed in the United States on November 27, 2006
B
Brian Zaleski
Alexandria, US
★★★★★ 5
Hilarious book
Format: Paperback
One of the funniest books to read. Packed with delightful humor to bring smiles the entire Christmas season. Difficult to put down. Can read it again and laugh just as much.
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Reviewed in the United States on January 19, 2007
A
Verified Purchase
Andres Hoyos
Boise, US
★★★★★ 5
Excellent customer service
Format: Paperback
Totally recommendable.
WAS THIS REVIEW HELPFUL?YesReportShare
Reviewed in the United States on August 26, 2019

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