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Description
IL-31RA Fc Chimera Protein, MouseProduct Specification Species Mouse Synonyms IL 31 receptor subunit alpha, IL 31R subunit alpha, IL 31R alpha, IL 31RA Accession Q8K5B1 1 Amino Acid Sequence Val19 Thr499, with C terminal Human IgG1 Fc
Product Specification
| Species | Mouse |
| Synonyms | IL-31 receptor subunit alpha, IL-31R subunit alpha, IL-31R-alpha, IL-31RA |
| Accession | Q8K5B1-1 |
| Amino Acid Sequence | Val19-Thr499, with C-terminal Human IgG1 Fc VLPTKPENISCVFYFDRNLTCTWRPEKETNDTSYIVTLTYSYGKSNYSDNATEASYSFPRSCAMPPDICSVEVQAQNGDGKVKSDITYWHLISIAKTEPPIILSVNPICNRMFQIQWKPREKTRGFPLVCMLRFRTVNSSHWTEVNFENCKQVCNLTGLQAFTEYVLALRFRFNDSRYWSKWSKEETRVTMEEVPHVLDLWRILEPADMNGDRKVRLLWKKARGAPVLEKTFGYHIQYFAENSTNLTEINNITTQQYELLLMSQAHSVSVTSFNSLGKSQEAILRIPDVHEKTFQYIKSMKAYIAEPLLVVNWQSSIPAVDTWIVEWLPEAAMSKFPALSWESVSQVTNWTIEQDKLKPFTCYNISVYPVLGHRVGEPYSIQAYAKEGTPLKGPETRVENIGLRTATITWKEIPKSARNGFINNYTVFYQAEGGKELSKTVNSHALQCDLESLTRRTSYTVWVMASTRAGGTNGVRINFKTIEGRMDPKSSDKTHTCPPCPAPELLGGPSVFLFPPKPKDTLMISRTPEVTCVVVDVSHEDPEVKFNWYVDGVEVHNAKTKPREEQYNSTYRVVSVLTVLHQDWLNGKEYKCKVSNKALPAPIEKTISKAKGQPREPQVYTLPPSRDELTKNQVSLTCLVKGFYPSDIAVEWESNGQPENNYKTTPPVLDSDGSFFLYSKLTVDKSRWQQGNVFSCSVMHEALHNHYTQKSLSLSPGK |
| Expression System | HEK293 |
| Molecular Weight | 97-120kDa |
| Purity | >95% by SDS-PAGE |
| Endotoxin | <0.1EU/μg |
| Conjugation | Unconjugated |
| Tag | Human Fc |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, pH7.4 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage |
· 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference | 1. Dillon, S. R. et al. (2004) Nat. Immunol. 5:752. 2. Chattopadhyay, S. et al. (2007) J. Biol. Chem. 282:3014. 3. Perrigoue, J. G. et al. (2007) J. Exp. Med. 204:481. 4. Bando, T. et al. (2006) Neuroscience 142:1263. |
Background
Interleukin-31 receptor subunit alpha (IL-31RA) is a protein that in humans is encoded by the IL31RA gene, also known as IL-31 receptor subunit alpha. The IL-31RA belongs to the type I cytokine receptor family. The 732 amino acid (aa) IL-31 RA contains signal sequence, extracellular domain (ECD), transmembrane domain and cytoplasmic domain. IL-31RA with homology to gp130, is expressed on monocytes, and is involved in IL-31 signaling via activation of STAT-3 and STAT-5. IL-31 RA is also expressed on keratinocytes, dorsal root ganglia neurons, and variably on lung epithelial cells. IL-31RA functions either as a monomer, or as part of a receptor complex with oncostatin M receptor (OSMR).
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