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Description
Equine CD8 Mouse mAb (S-1108-46)Product Specification Host Mouse Antigen Equine CD8 Synonyms T cell surface glycoprotein CD8 alpha chain Immunogen Recombinant Protein Location Cell membrane Accession F7BJE5 Clone Number S 1108 46 Antibody Type Mouse mAb Isotype IgG2a,k Application ELISA Reactivity Hr Purification Protein A Concentration 5 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS, 40% Glycerol, 0. 05% BSA, 0. 03% Proclin 300 Stability & Storage 12
Product Specification
| Host | Mouse |
| Antigen | Equine CD8 |
| Synonyms | T-cell surface glycoprotein CD8 alpha chain |
| Immunogen | Recombinant Protein |
| Location | Cell membrane |
| Accession | F7BJE5 |
| Clone Number | S-1108-46 |
| Antibody Type | Mouse mAb |
| Isotype | IgG2a,k |
| Application | ELISA |
| Reactivity | Hr |
| Purification | Protein A |
| Concentration | 5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Background
CD8 is a transmembrane glycoprotein that serves as a co-receptor for the T-cell receptor (TCR), playing a crucial role in T cell signaling and aiding cytotoxic T cell-antigen interactions. It binds specifically to the MHC class I protein, enhancing the affinity between the T cell receptor of cytotoxic T cells and target cells during antigen-specific activation. CD8 exists in two isoforms, alpha (CD8A) and beta (CD8B), each encoded by a different gene located on chromosome 2 in humans. The active form of CD8 is a dimer, with three different dimers detected: CD8αα, CD8αβ, and CD8ββ. This co-receptor also plays a role in T cell signaling by binding Lck (lymphocyte-specific protein tyrosine kinase) via its cytoplasmic tail, initiating a cascade of phosphorylation that leads to the activation of transcription factors and affects gene expression.
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