SKU: 56892176381

Invivo Anti-Mouse IL-4 Recombinant mAb

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Description

Invivo Anti-Mouse IL-4 Recombinant mAbProduct Specification Host Rat Antigen IL 4 Synonyms Interleukin 4; B cell IgG differentiation factor; B cell growth factor 1; B cell stimulatory factor 1 (BSF 1); IGG1 induction factor; Lymphocyte stimulatory factor 1; Il 4; Il4 Location Secreted Accession P07750 Clone Number S 3840 Antibody Type Rat mAb Isotype Rat IgG1,k Application ELISA, WB, in vivo IL 4 neutralization, in vitro IL 4 neutralization, in vivo IL 4 receptor stimulation (as a complex

Product Specification


Host Rat
Antigen IL-4
Synonyms Interleukin-4; B-cell IgG differentiation factor; B-cell growth factor 1; B-cell stimulatory factor 1 (BSF-1); IGG1 induction factor; Lymphocyte stimulatory factor 1; Il-4; Il4
Location Secreted
Accession P07750
Clone Number S-3840
Antibody Type Rat mAb
Isotype Rat IgG1,k
Application ELISA, WB, in vivo IL-4 neutralization, in vitro IL-4 neutralization, in vivo IL-4 receptor stimulation (as a complex with IL-4)
Purification Protein G
Concentration 5 mg/ml
Purity >95%(Determined by SDS-PAGE)
Endotoxin <1EU/mg
Conjugation Unconjugated
Physical Appearance Liquid
Storage Buffer

PBS pH7.4, containing no preservative

Stability & Storage

2 to 8 °C for 2 weeks under sterile conditions;
-20 °C for 3 months under sterile conditions;
-80 °C for 24 months under sterile conditions.
Please avoid repeated freeze-thaw cycles.

Dilution


application dilution species
WB 1:1000-1:50000 Ms

Background

Interleukin-4 (IL-4) is a 15–20 kDa, glycosylated, four-α-helical cytokine secreted primarily by Th2-polarized CD4⁺ T cells, mast cells, basophils and eosinophils that signals through a heterodimeric receptor complex composed of the IL-4Rα chain paired with either the common γ chain (type I, hemopoietic cells) or the IL-13Rα1 chain (type II, non-hemopoietic cells) to activate JAK1/3–STAT6 and IRS1/2 pathways, thereby driving commitment of naïve CD4⁺ T cells to the Th2 lineage, promoting immunoglobulin class-switching to IgG1 and IgE in B cells, inducing alternative activation (M2) of macrophages that orchestrate tissue repair and fibrosis, stimulating mucus production and smooth muscle remodeling in airway epithelium, and acting as a central mediator of allergic inflammation, asthma pathogenesis and resistance to helminth parasites, while also exerting context-dependent anti-inflammatory effects that limit Th1/Th17 responses and autoimmune damage.

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SKU: 56892176381

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2BMSALG😎😎😎
Pawtucket, US
★★★★★ 5
Must have👏🏾👏🏾👏🏾👏🏾
Format: Hardcover
Excellent hardcover and a must to a collection of history that many may not know. Take the journey that many will never understand 👏🏾💜🙌🏾
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Reviewed in the United States on April 28, 2026
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Dglana
West Palm Beach, US
★★★★★ 5
a beautiful important history book
Format: Hardcover
What an amazing book! This book is the version with incredible photos as part of the history story. I couldn't believe how vivid this was when I opened up the book. I'd been wanting the book for a while, because so little is told of the enslaved people's history in this country. It is important for us to understand our past, and without books like this one we do not have the full story. Thank you to the authors who put together this beautiful book.
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Reviewed in the United States on October 22, 2025
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Matthew Gregory
Boise, US
★★★★★ 5
This book is well written, insightful and well illustrated.
Format: Hardcover
Very interesting, well written and illustrated book. I haven’t experienced this through the eyes of people other than myself. We all believe we are on the correct side of history but the truth is a very strong thing when introduced to you. The truth is a beacon to the feet of our country as we move forward but we have gone off path. Thankfully it is not too late because we are all human.
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Reviewed in the United States on October 28, 2025
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Rob Byrd
Massapequa, US
★★★★★ 5
Saw this book at the African American Museum and had to have it!
Format: Hardcover
Excellent book, and the pictures give more realism to history!
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Reviewed in the United States on February 17, 2026
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Tasha Chambers
Draper, US
★★★★★ 5
Amazing
Format: Hardcover
This book is amazing!!!! The illustration is on point!!!! Love everything about this book!!!! A must have for every family!!!!!
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Reviewed in the United States on October 12, 2025

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