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Description
TAZ Recombinant Rabbit mAb (S-2812-102)Product Specification Host Rabbit Antigen TAZ Synonyms WW domain containing transcription regulator protein 1; Transcriptional coactivator with PDZ binding motif; TAZ s; WWTR1 Immunogen Synthetic Peptide Location Cytoplasm, Nucleus, Cell membrane Accession Q9GZV5 Clone Number S 2812 102 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P, ICC, ChIP Reactivity Hu, Ms, Mk Positive Sample A549, HepG2, HeLa, NIH 3T3, COS 7 Purification Protein
Product Specification
| Host | Rabbit |
| Antigen | TAZ |
| Synonyms | WW domain-containing transcription regulator protein 1; Transcriptional coactivator with PDZ-binding motif; TAZ s; WWTR1 |
| Immunogen | Synthetic Peptide |
| Location | Cytoplasm, Nucleus, Cell membrane |
| Accession | Q9GZV5 |
| Clone Number | S-2812-102 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P, ICC, ChIP |
| Reactivity | Hu, Ms, Mk |
| Positive Sample | A549, HepG2, HeLa, NIH/3T3, COS-7 |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu, Ms, Mk |
| IHC-P | 1:1000 | Hu |
| ICC | 1:50 | Hu, Ms |
| ChIP | 1:20-1:50 | Hu |
Background
TAZ (Transcriptional Co-activator with PDZ-binding motif), a 43 kDa paralog of YAP, is a mechanosensitive transcriptional co-activator that shuttles between the cytoplasm and nucleus to drive proliferation, stemness and epithelial-mesenchymal transition by partnering primarily with TEAD factors; it is negatively controlled by the Hippo kinases LATS1/2 through phosphorylation-dependent degradation, but can be de-phosphorylated and activated by PP1/ASPP2 or via GPCR-Rho signaling, and its chronic hyper-activation is strongly linked to tumor progression, metastasis and therapy resistance in multiple solid cancers.
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