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Description
IL-16(121aa) Protein, HumanProduct Specification Species Human Synonyms LCF; NIL16; PRIL16; prIL 16 Accession Q14005 Amino Acid Sequence Ser1212 Ser1332 Expression System E. coli Molecular Weight 17. 0 kD (Reducing) Purity > 95% by SDS PAGE Conjugation Unconjugated Tag No Tag Physical Appearance Lyophilized Powder Storage Buffer PBS, PH7. 4 Reconstitution Reconstitute at 0. 1 1 mg ml according to the size in ultrapure water after rapid centrifugation. Stability & Storage 12
Product Specification
| Species | Human |
| Synonyms | LCF; NIL16; PRIL16; prIL-16 |
| Accession | Q14005 |
| Amino Acid Sequence | Ser1212-Ser1332 |
| Expression System | E.coli |
| Molecular Weight | 17.0 kD (Reducing) |
| Purity | > 95% by SDS-PAGE |
| Conjugation | Unconjugated |
| Tag | No Tag |
| Physical Appearance | Lyophilized Powder |
| Storage Buffer | PBS, PH7.4 |
| Reconstitution | Reconstitute at 0.1-1 mg/ml according to the size in ultrapure water after rapid centrifugation. |
| Stability & Storage | · 12 months from date of receipt, lyophilized powder stored at -20 to -80℃. · 3 months, -20 to -80℃ under sterile conditions after reconstitution. · 1 week, 2 to 8℃ under sterile conditions after reconstitution. · Please avoid repeated freeze-thaw cycles. |
| Reference | William Cruikshank. Crit Rev Immunol. 2008;28(6):467-83. |
Background
Intcrleukin-16 (IL-16) was originally identified in 1980 as the first-described T-cell chemoattractant. Since that time, the protein has been cloned, sequenced, and characterized in terms of expression and biologic function for regulating inflammation. Generated as a precursor molecule, IL-16 is cleaved by caspase-3, yielding pro-IL-16 and the secreted (mature) portion. Both components of IL-16 are now known to regulate T-cell growth and represent one of the few proteins for which function has been determined for both the pro- and secreted portions. Secreted IL-16 primes CD4+ T cells for IL-2 and IL-15 responsiveness, with a preferential effect on TH1 cells. Animal models have identified its involvement in the establishment of TH1-type inflammation with a critical role in the development of certain autoimmune diseases. Nuclear pro-IL-16 is a recently identified regulator of Skp2 transcription and T- cell cycle progression, acting as a scaffold protein for GABPbeta and histone deacctylase-3.
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