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Description
CD61 Recombinant Rabbit mAb (S-2515-6)Product Specification Host Rabbit Antigen CD61 Synonyms Integrin beta 3; Platelet membrane glycoprotein IIIa (GPIIIa); GP3A; ITGB3 Immunogen Synthetic Peptide Location Cell membrane, Cell projection Accession P05106 Clone Number S 2515 6 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P, IF Reactivity Hu, Ms, Rt, Mk Positive Sample U 87 MG, HUVEC, C2C12, RAW264. 7, mouse spleen, COS 7, rat spleen Purification Protein A Concentration 0. 5
Product Specification
| Host | Rabbit |
| Antigen | CD61 |
| Synonyms | Integrin beta-3; Platelet membrane glycoprotein IIIa (GPIIIa); GP3A; ITGB3 |
| Immunogen | Synthetic Peptide |
| Location | Cell membrane, Cell projection |
| Accession | P05106 |
| Clone Number | S-2515-6 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P, IF |
| Reactivity | Hu, Ms, Rt, Mk |
| Positive Sample | U-87 MG, HUVEC, C2C12, RAW264.7, mouse spleen, COS-7, rat spleen |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu, Ms, Rt, Mk |
| IHC-P | 1:500-1:2000 | Hu, Ms, Rt |
| IF | 1:500 | Hu |
Background
CD61, also known as integrin beta-3 (ITGB3) or glycoprotein IIIa (gpIIIa), is a transmembrane protein encoded by the ITGB3 gene in humans. It is predominantly expressed on the surface of platelets and megakaryocytes. CD61 forms a crucial complex with CD41 (alphaIIb) to create the heterodimeric receptor gpIIb/IIIa, which is essential for platelet aggregation and thrombus formation. This receptor binds to fibrinogen, von Willebrand factor, and other extracellular matrix proteins, facilitating platelet adhesion and aggregation. In addition to its role in hemostasis, CD61 is also involved in various cellular processes, including cell adhesion, migration, and proliferation. It has been implicated in tumor progression, where it can influence tumor metabolism, immune microenvironment, and epithelial-to-mesenchymal transition.
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