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Description
S-RMab® CD3 epsilon Recombinant Rabbit mAb (SDT-R137)Product Specification Host Rabbit Antigen CD3 EPSILON Synonyms T cell surface antigen T3 Leu 4 epsilon chain, CD3e, T3E, CD3E Immunogen N A Location Cell membrane Accession P07766 Clone Number SDT R137 Antibody Type Recombinant mAb Application WB, IHC P, IP Reactivity Hu, Ms, Rt Purification Protein A Concentration 0. 25 mg ml Tag N A Physical Appearance Liquid Storage Buffer PBS, 40% Glycerol, 0. 05% BSA, 0. 03% Proclin 300 Stability & Storage 12
Product Specification
| Host | Rabbit |
| Antigen | CD3 EPSILON |
| Synonyms | T-cell surface antigen T3/Leu-4 epsilon chain, CD3e, T3E, CD3E |
| Immunogen | N/A |
| Location | Cell membrane |
| Accession | P07766 |
| Clone Number | SDT-R137 |
| Antibody Type | Recombinant mAb |
| Application | WB, IHC-P, IP |
| Reactivity | Hu, Ms, Rt |
| Purification | Protein A |
| Concentration | 0.25 mg/ml |
| Tag | N/A |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:500 | |
| IHC-P | 1:1000-1:2000 | |
| IP | 1:25 |
Background
CD3 (cluster of differentiation 3) is a protein complex and T cell co-receptor that is involved in activating both the cytotoxic T cell (CD8+ naive T cells) and T helper cells (CD4+ naive T cells). It is composed of four distinct chains. In mammals, the complex contains a CD3γ chain, a CD3δ chain, and two CD3ε chains. These chains associate with the T-cell receptor (TCR) and the CD3-zeta (ζ-chain) to generate an activation signal in T lymphocytes. The TCR, CD3-zeta, and the other CD3 molecules together constitute the TCR complex. The CD3–T cell receptor (TCR) complex plays a central role in the T-cell-mediated immunoresponse as it is involved in the recognition of antigens and subsequent signal transduction and activation of immunocompetent T lymphocytes. Because CD3 is required for T cell activation, drugs (often monoclonal antibodies) that target it are being investigated as immunosuppressant therapies (e.g., otelixizumab, teplizumab) for type 1 diabetes and other autoimmune diseases.
Shipping Notes
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Exchange/Return Notes
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