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Description
GFAP Recombinant Mouse mAb (SDT-3032)Product Specification Host Mouse Antigen GFAP Synonyms Glial fibrillary acidic protein Location Cytoplasm Accession P14136 Clone Number SDT 3032 Antibody Type Recombinant mAb Isotype IgG1,k Application IHC P Reactivity Hu Purification Protein G Concentration 2 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS, 40% Glycerol, 0. 05% BSA, 0. 03% Proclin 300 Stability & Storage 12 months from date of receipt reconstitution, 20 C
Product Specification
| Host | Mouse |
| Antigen | GFAP |
| Synonyms | Glial fibrillary acidic protein |
| Location | Cytoplasm |
| Accession | P14136 |
| Clone Number | SDT-3032 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG1,k |
| Application | IHC-P |
| Reactivity | Hu |
| Purification | Protein G |
| Concentration | 2 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| IHC-P | 1:1000 | Hu |
Background
Glial fibrillary acidic protein (GFAP) is a type of intermediate filament protein that is primarily expressed in astrocytes, which are a kind of glial cells in the central nervous system. It plays a crucial role in maintaining the structural integrity of astrocytes and providing support to neurons. GFAP helps to anchor astrocytes to the extracellular matrix and other cells, contributing to the stability of the brain tissue. Additionally, it is involved in various cellular processes such as cell signaling, migration, and proliferation of astrocytes. In clinical practice, elevated levels of GFAP in cerebrospinal fluid or blood can be an indicator of certain neurological disorders like traumatic brain injury, brain tumors, and neurodegenerative diseases, making it a potentially valuable biomarker for diagnosis and monitoring of these conditions.
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