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Description
FOXC1 Recombinant Rabbit mAb (S-1607-142)Product Specification Host Rabbit Antigen FOXC1 Synonyms Forkhead box protein C1; Forkhead related protein FKHL7; Forkhead related transcription factor 3 (FREAC 3); FKHL7; FREAC3 Immunogen Synthetic Peptide Location Nucleus Accession Q12948 Clone Number S 1607 142 Antibody Type Recombinant mAb Isotype IgG Application WB, IHC P, ICC Reactivity Hu, Ms, Rt Positive Sample HeLa, LoVo, NIH 3T3, C6 Purification Protein A Concentration 0. 5 mg ml Conjugation
Product Specification
| Host | Rabbit |
| Antigen | FOXC1 |
| Synonyms | Forkhead box protein C1; Forkhead-related protein FKHL7; Forkhead-related transcription factor 3 (FREAC-3); FKHL7; FREAC3 |
| Immunogen | Synthetic Peptide |
| Location | Nucleus |
| Accession | Q12948 |
| Clone Number | S-1607-142 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB, IHC-P, ICC |
| Reactivity | Hu, Ms, Rt |
| Positive Sample | HeLa, LoVo, NIH/3T3, C6 |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:500-1:1000 | Hu, Ms, Rt |
| IHC-P | 1:250 | Hu, Ms, Rt |
| ICC | 1:100 | Hu |
Background
FOXC1 is a 553-amino-acid forkhead/winged-helix transcription factor encoded by the single-exon gene on 6p25 that orchestrates embryogenesis, ocular, cardiovascular, renal, cerebellar, and skeletal development by binding DNA through its conserved forkhead domain to regulate target genes; dosage-sensitive FOXC1 expression is essential, as mutations or copy-number alterations produce Axenfeld–Rieger syndrome with anterior-segment eye malformations and secondary glaucoma, while in cancer FOXC1 drives epithelial–mesenchymal transition, metastasis, and stem-cell self-renewal via pathways such as STI-1/PrPC or DNMT3B-mediated DNA methylation, and during bone formation it partners with GATA4 to control Runx2-dependent osteoblast differentiation .
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