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Description
MC5R Recombinant Rabbit mAb (S-3142-41)Product Specification Host Rabbit Antigen MC5R Synonyms Melanocortin receptor 5; MC5 R; MC 2 Immunogen Synthetic Peptide Location Cell membrane Accession P33032 Clone Number S 3142 41 Antibody Type Recombinant mAb Isotype IgG Application WB Reactivity Hu, Ms, Rt Positive Sample K562, U 87 MG, HepG2, mouse brain, mouse testis, rat brain, rat testis Predicted Reactivity Cz Purification Protein A Concentration 0. 5 mg ml Conjugation Unconjugated Physical
Product Specification
| Host | Rabbit |
| Antigen | MC5R |
| Synonyms | Melanocortin receptor 5; MC5-R; MC-2 |
| Immunogen | Synthetic Peptide |
| Location | Cell membrane |
| Accession | P33032 |
| Clone Number | S-3142-41 |
| Antibody Type | Recombinant mAb |
| Isotype | IgG |
| Application | WB |
| Reactivity | Hu, Ms, Rt |
| Positive Sample | K562, U-87 MG, HepG2, mouse brain, mouse testis, rat brain, rat testis |
| Predicted Reactivity | Cz |
| Purification | Protein A |
| Concentration | 0.5 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | Hu, Ms, Rt |
Background
MC5R, a 325-amino-acid G-protein-coupled receptor encoded by MC5R on chromosome 18p11.2, is the most promiscuous of the five melanocortin receptors, binding α-, β- and γ-MSH as well as ACTH with nanomolar affinity to activate Gαs/cAMP signaling; it is highly expressed in sebaceous, lacrimal, meibomian and preputial glands, driving lipid-rich secretions that waterproof skin and hair, modulate thermoregulation, scent marking and innate immunity, and its global or sebocyte-specific deletion in mice produces a severe “dry coat” phenotype, altered sebum lipidomes, increased transepidermal water loss and susceptibility to dermatitis, while in humans MC5R polymorphisms correlate with acne severity and seborrheic dermatitis, making it a promising, highly tissue-restricted target for next-generation topical or systemic therapeutics aimed at controlling sebum output, dry eye, androgen-independent acne, and even metabolic syndrome through its recently discovered roles in adipose tissue lipolysis and hepatic steatosis.
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