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Description
Rat-Anti Mouse PD-1 Antibody (S-798-5)Product Specification Host Rat Antigen PD 1 Synonyms Programmed cell death protein 1, Protein PD 1, mPD 1, CD279, Pdcd1 Immunogen Recombinant Protein Location Cell membrane Accession Q02242 Clone Number S 798 5 Antibody Type Rat mAb Isotype IgG1,k Application WB, ICC, FCM Reactivity Ms Concentration 2 mg ml Conjugation Unconjugated Physical Appearance Liquid Storage Buffer PBS, 40% Glycerol, 0. 05% BSA, 0. 03% Proclin 300 Stability & Storage 12 months
Product Specification
| Host | Rat |
| Antigen | PD-1 |
| Synonyms | Programmed cell death protein 1, Protein PD-1, mPD-1, CD279, Pdcd1 |
| Immunogen | Recombinant Protein |
| Location | Cell membrane |
| Accession | Q02242 |
| Clone Number | S-798-5 |
| Antibody Type | Rat mAb |
| Isotype | IgG1,k |
| Application | WB, ICC, FCM |
| Reactivity | Ms |
| Concentration | 2 mg/ml |
| Conjugation | Unconjugated |
| Physical Appearance | Liquid |
| Storage Buffer | PBS, 40% Glycerol, 0.05% BSA, 0.03% Proclin 300 |
| Stability & Storage | 12 months from date of receipt / reconstitution, -20 °C as supplied |
Dilution
| application | dilution | species |
| WB | 1:1000 | |
| ICC | 1:100 | |
| FCM | 1:2000 |
Background
Programmed cell death protein 1, also known as PD-1 and CD279 (cluster of differentiation 279), is a protein on the surface of T and B cells that has a role in regulating the immune system's response to the cells of the human body by down-regulating the immune system and promoting self-tolerance by suppressing T cell inflammatory activity. This prevents autoimmune diseases, but it can also prevent the immune system from killing cancer cells. PD-1 is an immune checkpoint and guards against autoimmunity through two mechanisms. First, it promotes apoptosis (programmed cell death) of antigen-specific T-cells in lymph nodes. Second, it reduces apoptosis in regulatory T cells (anti-inflammatory, suppressive T cells).
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